Organotypic Models to Study Human Glioblastoma : Studying the Beast in Its Ecosystem

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2020
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Pamies, David
Zurich, Marie-Gabrielle
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iScience. Elsevier. 2020, 23(10), 101633. ISSN 2589-0042. eISSN 2589-0042. Available under: doi: 10.1016/j.isci.2020.101633
Zusammenfassung

Glioblastoma is a very aggressive primary brain tumor in adults, with very low survival rates and no curative treatments. The high failure rate of drug development for this cancer is linked to the high-cost, time-consuming, and inefficient models used to study the disease. Advances in stem cell and in vitro cultures technologies are promising, however, and here we present the advantages and limitations of available organotypic culture models and discuss their possible applications for studying glioblastoma.

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570 Biowissenschaften, Biologie
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ISO 690PAMIES, David, Marie-Gabrielle ZURICH, Thomas HARTUNG, 2020. Organotypic Models to Study Human Glioblastoma : Studying the Beast in Its Ecosystem. In: iScience. Elsevier. 2020, 23(10), 101633. ISSN 2589-0042. eISSN 2589-0042. Available under: doi: 10.1016/j.isci.2020.101633
BibTex
@article{Pamies2020-10-23Organ-52307,
  year={2020},
  doi={10.1016/j.isci.2020.101633},
  title={Organotypic Models to Study Human Glioblastoma : Studying the Beast in Its Ecosystem},
  number={10},
  volume={23},
  issn={2589-0042},
  journal={iScience},
  author={Pamies, David and Zurich, Marie-Gabrielle and Hartung, Thomas},
  note={Article Number: 101633}
}
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