Apoptosis in the Dorsal Lateral Geniculate Nucleus after Monocular Deprivation Involves Glutamate Signaling, NO Production, and PARP Activation

Nucci, Carlo; Piccirilli, Silvia; Rodinò, Paola; Nisticò, Robert; Grandinetti, Marina; Cerulli, Luciano; Leist, Marcel; Nicotera, Pierluigi; Bagetta, Giacinto

Apoptosis in the Dorsal Lateral Geniculate Nucleus after Monocular Deprivation Involves Glutamate Signaling, NO Production, and PARP Activation

Dateien

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Datum

2000

Autor:innen

Nucci, Carlo

Piccirilli, Silvia

Rodinò, Paola

Nisticò, Robert

Grandinetti, Marina

Cerulli, Luciano

Leist, Marcel

Nicotera, Pierluigi

Bagetta, Giacinto

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Biochemical and Biophysical Research Communications. 2000, 278(2), pp. 360-367. ISSN 0006-291X. eISSN 1090-2104. Available under: doi: 10.1006/bbrc.2000.3811

Zusammenfassung

In mammals, visual experience during early postnatal life is critical for normal development of the visual system. Here we report that monocular deprivation for 2, 7, and 14 consecutive days causes p53 accumulation, cell death, and progressive loss of neurones in the dorsal lateral geniculate nucleus (dLGN) of newborn rats and these are prevented by NMDA and non-NMDA glutamate receptor antagonists, and by L-NAME, an inhibitor of nitric oxide synthesis. Monocular deprivation also increases dLGN levels of citrulline, the coproduct of nitric oxide synthesis, and this, as well as cell death and neuronal loss, is abolished by antagonists of glutamate receptors and by L-NAME. Finally, poly-(ADP-ribose) polymerase (PARP) knock-out mice appear to be protected from monocular deprivation-induced cell death. In conclusion, during early postnatal development of the rat visual system monocular deprivation causes excitotoxic, nitric oxide-mediated, cell death in the dLGN that appears to be apoptotic and also requires activation of PARP.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

NUCCI, Carlo, Silvia PICCIRILLI, Paola RODINÒ, Robert NISTICÒ, Marina GRANDINETTI, Luciano CERULLI, Marcel LEIST, Pierluigi NICOTERA, Giacinto BAGETTA, 2000. Apoptosis in the Dorsal Lateral Geniculate Nucleus after Monocular Deprivation Involves Glutamate Signaling, NO Production, and PARP Activation. In: Biochemical and Biophysical Research Communications. 2000, 278(2), pp. 360-367. ISSN 0006-291X. eISSN 1090-2104. Available under: doi: 10.1006/bbrc.2000.3811

BibTex

@article{Nucci2000-11-19Apopt-40835,
  year={2000},
  doi={10.1006/bbrc.2000.3811},
  title={Apoptosis in the Dorsal Lateral Geniculate Nucleus after Monocular Deprivation Involves Glutamate Signaling, NO Production, and PARP Activation},
  number={2},
  volume={278},
  issn={0006-291X},
  journal={Biochemical and Biophysical Research Communications},
  pages={360--367},
  author={Nucci, Carlo and Piccirilli, Silvia and Rodinò, Paola and Nisticò, Robert and Grandinetti, Marina and Cerulli, Luciano and Leist, Marcel and Nicotera, Pierluigi and Bagetta, Giacinto}
}

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