p63 the guardian of human reproduction

Amelio, Ivano; Grespi, Francesca; Annicchiarico-Petruzzelli, Margherita; Melino, Gerry

p63 the guardian of human reproduction

Dateien

Amelio_2-1rxfc2cj33f9y0.pdfGröße: 572.5 KBDownloads: 33

Datum

2012

Autor:innen

Amelio, Ivano

Grespi, Francesca

Annicchiarico-Petruzzelli, Margherita

Melino, Gerry

Open Access-Veröffentlichung

Open Access Hybrid

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Cell cycle. Taylor & Francis. 2012, 11(24), pp. 4545-4551. ISSN 1538-4101. eISSN 1551-4005. Available under: doi: 10.4161/cc.22819

Zusammenfassung

p63 is a transcriptional factor implicated in cancer and development. The presence in TP63 gene of alternative promoters allows expression of one isoform containing the N-terminal transactivation domain (TA isoform) and one N-terminal truncated isoform (ΔN isoform). Complete ablation of all p63 isoforms produced mice with fatal developmental abnormalities, including lack of epidermal barrier, limbs and other epidermal appendages. Specific TAp63-null mice, although they developed normally, failed to undergo in DNA damage-induced apoptosis during primordial follicle meiotic arrest, suggesting a p63 involvement in maternal reproduction. Recent findings have elucidated the role in DNA damage response of a novel Hominidae p63 isoform, GTAp63, specifically expressed in human spermatic precursors. Thus, these findings suggest a unique strategy of p63 gene, to evolve in order to preserve the species as a guardian of reproduction. Elucidation of the biological basis of p63 function in reproduction may provide novel approaches to the control of human fertility.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

p63, oocytes, spermatozoa, reproduction, DNA damage, p53, c-Abl

Zitieren

ISO 690

AMELIO, Ivano, Francesca GRESPI, Margherita ANNICCHIARICO-PETRUZZELLI, Gerry MELINO, 2012. p63 the guardian of human reproduction. In: Cell cycle. Taylor & Francis. 2012, 11(24), pp. 4545-4551. ISSN 1538-4101. eISSN 1551-4005. Available under: doi: 10.4161/cc.22819

BibTex

@article{Amelio2012-12-15guard-57106,
  year={2012},
  doi={10.4161/cc.22819},
  title={p63 the guardian of human reproduction},
  number={24},
  volume={11},
  issn={1538-4101},
  journal={Cell cycle},
  pages={4545--4551},
  author={Amelio, Ivano and Grespi, Francesca and Annicchiarico-Petruzzelli, Margherita and Melino, Gerry}
}

RDF

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/57106">
    <dc:contributor>Annicchiarico-Petruzzelli, Margherita</dc:contributor>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/57106/1/Amelio_2-1rxfc2cj33f9y0.pdf"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-31T06:07:16Z</dcterms:available>
    <dcterms:title>p63 the guardian of human reproduction</dcterms:title>
    <dc:contributor>Grespi, Francesca</dc:contributor>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/57106/1/Amelio_2-1rxfc2cj33f9y0.pdf"/>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:rights>terms-of-use</dc:rights>
    <dcterms:abstract xml:lang="eng">p63 is a transcriptional factor implicated in cancer and development. The presence in TP63 gene of alternative promoters allows expression of one isoform containing the N-terminal transactivation domain (TA isoform) and one N-terminal truncated isoform (ΔN isoform). Complete ablation of all p63 isoforms produced mice with fatal developmental abnormalities, including lack of epidermal barrier, limbs and other epidermal appendages. Specific TAp63-null mice, although they developed normally, failed to undergo in DNA damage-induced apoptosis during primordial follicle meiotic arrest, suggesting a p63 involvement in maternal reproduction. Recent findings have elucidated the role in DNA damage response of a novel Hominidae p63 isoform, GTAp63, specifically expressed in human spermatic precursors. Thus, these findings suggest a unique strategy of p63 gene, to evolve in order to preserve the species as a guardian of reproduction. Elucidation of the biological basis of p63 function in reproduction may provide novel approaches to the control of human fertility.</dcterms:abstract>
    <dc:creator>Melino, Gerry</dc:creator>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/57106"/>
    <dc:contributor>Amelio, Ivano</dc:contributor>
    <dc:contributor>Melino, Gerry</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:issued>2012-12-15</dcterms:issued>
    <dc:language>eng</dc:language>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-31T06:07:16Z</dc:date>
    <dc:creator>Amelio, Ivano</dc:creator>
    <dc:creator>Annicchiarico-Petruzzelli, Margherita</dc:creator>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Grespi, Francesca</dc:creator>
  </rdf:Description>
</rdf:RDF>

Universitätsbibliographie

Nein

Begutachtet

Ja