@article{Amelio2013-11-14miR24-57121,
  year={2013},
  doi={10.1038/cddis.2013.426},
  title={miR-24 affects hair follicle morphogenesis targeting Tcf-3},
  number={11},
  volume={4},
  journal={Cell death & disease},
  author={Amelio, Ivano and Lena, Anna Maria and Bonanno, Elena and Melino, Gerry and Candi, Eleonora},
  note={Article Number: e922}
}

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    <dc:contributor>Lena, Anna Maria</dc:contributor>
    <dc:creator>Amelio, Ivano</dc:creator>
    <dc:contributor>Candi, Eleonora</dc:contributor>
    <dc:contributor>Melino, Gerry</dc:contributor>
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    <dc:creator>Melino, Gerry</dc:creator>
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    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-31T13:25:01Z</dc:date>
    <dc:contributor>Bonanno, Elena</dc:contributor>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/57121"/>
    <dcterms:title>miR-24 affects hair follicle morphogenesis targeting Tcf-3</dcterms:title>
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    <dc:contributor>Amelio, Ivano</dc:contributor>
    <dcterms:abstract xml:lang="eng">During embryonic development, hair follicles (HFs) develop from an epidermal-mesenchymal cross talk between the ectoderm progenitor layer and the underlying dermis. Epidermal stem cell activation represents a crucial point both for HF morphogenesis and for hair regeneration. miR-24 is an anti-proliferative microRNA (miRNA), which is induced during differentiation of several cellular systems including the epidermis. Here, we show that miR-24 is expressed in the HF and has a role in hair morphogenesis. We generated transgenic mice ectopically expressing miR-24 under the K5 promoter. The K5::miR-24 animals display a marked defect in HF morphogenesis, with thinning of hair coat and altered HF structure. Expression of miR-24 alters the normal process of hair keratinocyte differentiation, leading to altered expression of differentiation markers. MiR-24 directly represses the hair keratinocyte stemness regulator Tcf-3. These results support the notion that microRNAs, and among them miR-24, have an important role in postnatal epidermal homeostasis.</dcterms:abstract>
    <dcterms:issued>2013-11-14</dcterms:issued>
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    <dc:creator>Bonanno, Elena</dc:creator>
    <dc:creator>Candi, Eleonora</dc:creator>
    <dc:creator>Lena, Anna Maria</dc:creator>
    <dc:language>eng</dc:language>
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