On the Role of the Immunoproteasome in Protein Homeostasis

Basler, Michael; Gröttrup, Marcus

On the Role of the Immunoproteasome in Protein Homeostasis

Dateien

Basler_2-1tl7klorqzlg39.pdfGröße: 1.44 MBDownloads: 48

Datum

2021

Open Access-Veröffentlichung

Open Access Gold

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Cells. MDPI. 2021, 10(11), 3216. eISSN 2073-4409. Available under: doi: 10.3390/cells10113216

Zusammenfassung

Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation. The immunoproteasome is a special type of proteasome which is inducible under inflammatory conditions and constitutively expressed in hematopoietic cells. MECL-1 (β2i), LMP2 (β1i), and LMP7 (β5i) are the proteolytically active subunits of the immunoproteasome (IP), which is known to shape the antigenic repertoire presented on major histocompatibility complex (MHC) class I molecules. Furthermore, the immunoproteasome is involved in T cell expansion and inflammatory diseases. In recent years, targeting the immunoproteasome in cancer, autoimmune diseases, and transplantation proved to be therapeutically effective in preclinical animal models. However, the prime function of standard proteasomes and immunoproteasomes is the control of protein homeostasis in cells. To maintain protein homeostasis in cells, proteasomes remove proteins which are not properly folded, which are damaged by stress conditions such as reactive oxygen species formation, or which have to be degraded on the basis of regular protein turnover. In this review we summarize the latest insights on how the immunoproteasome influences protein homeostasis.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

BASLER, Michael, Marcus GRÖTTRUP, 2021. On the Role of the Immunoproteasome in Protein Homeostasis. In: Cells. MDPI. 2021, 10(11), 3216. eISSN 2073-4409. Available under: doi: 10.3390/cells10113216

BibTex

@article{Basler2021Immun-55762,
  year={2021},
  doi={10.3390/cells10113216},
  title={On the Role of the Immunoproteasome in Protein Homeostasis},
  number={11},
  volume={10},
  journal={Cells},
  author={Basler, Michael and Gröttrup, Marcus},
  note={Article Number: 3216}
}

RDF

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