@article{Maheshwari2020-06-16Postm-50655,
  year={2020},
  doi={10.1016/j.celrep.2020.107767},
  title={Postmitotic Hoxa5 Expression Specifies Pontine Neuron Positional Identity and Input Connectivity of Cortical Afferent Subsets},
  number={11},
  volume={31},
  issn={2211-1247},
  journal={Cell reports},
  author={Maheshwari, Upasana and Kraus, Dominik and Vilain, Nathalie and Maiorano, Nicola A. and Kohler, Hubertus and Satoh, Daisuke and Sigrist, Markus and Kratochwil, Claudius F. and Holwerda, Sjoerd J. B. and Cankovic, Vanja},
  note={Article Number: 107767}
}

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    <dc:creator>Kratochwil, Claudius F.</dc:creator>
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    <dc:creator>Maiorano, Nicola A.</dc:creator>
    <dc:contributor>Kohler, Hubertus</dc:contributor>
    <dc:contributor>Vilain, Nathalie</dc:contributor>
    <dc:contributor>Cankovic, Vanja</dc:contributor>
    <dc:contributor>Kraus, Dominik</dc:contributor>
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    <dc:creator>Satoh, Daisuke</dc:creator>
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    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-09-02T08:53:12Z</dc:date>
    <dcterms:title>Postmitotic Hoxa5 Expression Specifies Pontine Neuron Positional Identity and Input Connectivity of Cortical Afferent Subsets</dcterms:title>
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    <dc:contributor>Kratochwil, Claudius F.</dc:contributor>
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    <dcterms:abstract xml:lang="eng">The mammalian precerebellar pontine nucleus (PN) has a main role in relaying cortical information to the cerebellum. The molecular determinants establishing ordered connectivity patterns between cortical afferents and precerebellar neurons are largely unknown. We show that expression of Hox5 transcription factors is induced in specific subsets of postmitotic PN neurons at migration onset. Hox5 induction is achieved by response to retinoic acid signaling, resulting in Jmjd3-dependent derepression of Polycomb chromatin and 3D conformational changes. Hoxa5 drives neurons to settle posteriorly in the PN, where they are monosynaptically targeted by cortical neuron subsets mainly carrying limb somatosensation. Furthermore, Hoxa5 postmigratory ectopic expression in PN neurons is sufficient to attract cortical somatosensory inputs regardless of position and avoid visual afferents. Transcriptome analysis further suggests that Hoxa5 is involved in circuit formation. Thus, Hoxa5 coordinates postmitotic specification, migration, settling position, and sub-circuit assembly of PN neuron subsets in the cortico-cerebellar pathway.</dcterms:abstract>
    <dc:creator>Kraus, Dominik</dc:creator>
    <dc:creator>Kohler, Hubertus</dc:creator>
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    <dc:contributor>Sigrist, Markus</dc:contributor>
    <dc:creator>Sigrist, Markus</dc:creator>
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    <dc:contributor>Maheshwari, Upasana</dc:contributor>
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    <dc:contributor>Satoh, Daisuke</dc:contributor>
    <dc:creator>Holwerda, Sjoerd J. B.</dc:creator>
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