Brain Marker Links Stress and Nicotine Abstinence

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2020
Autor:innen
Allenby, Cheyenne
Falcone, Mary
Ashare, Rebecca L.
Cao, Wen
Bernardo, Leah
Wileyto, E. Paul
Loughead, James
Lerman, Caryn
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Nicotine & tobacco research. Oxford University Press (OUP). 2020, 22(6), pp. 885-891. eISSN 1469-994X. Available under: doi: 10.1093/ntr/ntz077
Zusammenfassung

Background: Subjective stress is a well-documented predictor of early smoking relapse, yet our understanding of stress and tobacco use is limited by reliance on self-reported measures of stress. We utilized a validated functional neuroimaging paradigm to examine whether stress exposure during early abstinence alters objective measures of brain function.

Methods: 75 participants underwent blood oxygen level dependent (BOLD) functional magnetic resonance imaging (FMRI) during the Montreal Imaging Stress Task (MIST) on two occasions: once during smoking satiety and once following biochemically confirmed 24-hour abstinence (order counter-balanced). The primary outcome measure was brain response during stress (vs. control) blocks of the MIST, assessed using whole-brain analysis corrected for multiple comparisons using clusters determined by Z≥3.1.

Results: Abstinence (vs. satiety) was associated with significantly increased activation in the left inferior frontal gyrus, a brain region associated with inhibitory control. Abstinence-induced change in brain response to stress was positively associated with change in self-reported stress.

Conclusions: This study provides objective evidence that the brain response to stress is altered during the first 24 hours of a quit attempt compared to smoking satiety.

Implications: These results point to the potential value of inoculating smokers with stress management training prior to a quit attempt.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
150 Psychologie
Schlagwörter
nicotine, smoking, satiation, brain, stress
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ISO 690ALLENBY, Cheyenne, Mary FALCONE, Rebecca L. ASHARE, Wen CAO, Leah BERNARDO, E. Paul WILEYTO, Jens C. PRUESSNER, James LOUGHEAD, Caryn LERMAN, 2020. Brain Marker Links Stress and Nicotine Abstinence. In: Nicotine & tobacco research. Oxford University Press (OUP). 2020, 22(6), pp. 885-891. eISSN 1469-994X. Available under: doi: 10.1093/ntr/ntz077
BibTex
@article{Allenby2020-06Brain-45922,
  year={2020},
  doi={10.1093/ntr/ntz077},
  title={Brain Marker Links Stress and Nicotine Abstinence},
  number={6},
  volume={22},
  journal={Nicotine & tobacco research},
  pages={885--891},
  author={Allenby, Cheyenne and Falcone, Mary and Ashare, Rebecca L. and Cao, Wen and Bernardo, Leah and Wileyto, E. Paul and Pruessner, Jens C. and Loughead, James and Lerman, Caryn}
}
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