Neurobiological Correlates and Predictors of Two Distinct Personality Trait Pathways to Escalated Alcohol Use

Lade...
Vorschaubild
Dateien
Shakra_2-4rhn6lv82sut7.pdf
Shakra_2-4rhn6lv82sut7.pdfGröße: 768.5 KBDownloads: 273
Datum
2018
Autor:innen
Shakra, Malak Abu
Leyton, Marco
Moghnieh, Hussein
Dagher, Alain
Pihl, Robert
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
ArXiv-ID
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Gold
Sammlungen
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
EBioMedicine. 2018, 27, pp. 86-93. ISSN 2352-3964. eISSN 2352-3964. Available under: doi: 10.1016/j.ebiom.2017.11.025
Zusammenfassung

Background
The delineation of the behavioral neurobiological mechanisms underlying the heterogeneous pathways for alcohol use disorders (AUDs) is ostensibly imperative for the development of more cost-effective treatments predicated on better understanding of this complex psychopathology.

Methods
1) Forty-eight high anxiety sensitive (HAS) and high sensation seeking (HSS) psychopathology-free emerging adults (mean (SD) age: 20.4 (1.9) years) completed a Face Emotion Processing Task and a social stress paradigm (Montreal Imaging Stress Task) during functional magnetic resonance imaging sessions with and without alcohol ingestion (1 ml/kg of 95% USP alcohol, p.o.). Drug and alcohol use was reassessed during follow-up interviews 2–3 years later.

Outcomes
The effects of alcohol (versus placebo) ingestion depended upon the task and risk group. In response to negative (versus neutral) faces, alcohol diminished amygdala (AMYG) activations in HAS but not HSS subjects. In response to psychosocial evaluative stress, alcohol enhanced activations of the medial orbitofrontal cortex (mOFC), perigenual anterior cingulate cortex, and nucleus accumbens in HAS male subjects (HASMS), but decreased mOFC activity in HSS male subjects (HSSMS). At follow-up, a greater alcohol versus placebo differential for threat-related AMYG activations predicted escalating drinking and/or illicit drug use among HAS but not HSS participants, whereas a greater differential for mOFC activations during acute social stress predicted escalating substance use among HSS but not HAS participants.

Interpretation
This double dissociation provides evidence of distinct neurobiological profiles in a priori identified personality trait-based risk groups for AUDs, and links these signatures to clinically relevant substance use outcomes at follow-up. AUD subtypes might benefit from motivationally and personality-specific ameliorative and preventative interventions.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
150 Psychologie
Schlagwörter
Alcohol; fMRI; Sensation seeking; Anxiety sensitivity; Amygdala; Orbitofrontal cortex
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690SHAKRA, Malak Abu, Marco LEYTON, Hussein MOGHNIEH, Jens C. PRUESSNER, Alain DAGHER, Robert PIHL, 2018. Neurobiological Correlates and Predictors of Two Distinct Personality Trait Pathways to Escalated Alcohol Use. In: EBioMedicine. 2018, 27, pp. 86-93. ISSN 2352-3964. eISSN 2352-3964. Available under: doi: 10.1016/j.ebiom.2017.11.025
BibTex
@article{Shakra2018-01Neuro-41152,
  year={2018},
  doi={10.1016/j.ebiom.2017.11.025},
  title={Neurobiological Correlates and Predictors of Two Distinct Personality Trait Pathways to Escalated Alcohol Use},
  volume={27},
  issn={2352-3964},
  journal={EBioMedicine},
  pages={86--93},
  author={Shakra, Malak Abu and Leyton, Marco and Moghnieh, Hussein and Pruessner, Jens C. and Dagher, Alain and Pihl, Robert}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/41152">
    <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 International</dc:rights>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/41152"/>
    <dc:creator>Leyton, Marco</dc:creator>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/41152/1/Shakra_2-4rhn6lv82sut7.pdf"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-01-25T09:53:37Z</dcterms:available>
    <dc:contributor>Pruessner, Jens C.</dc:contributor>
    <dc:creator>Dagher, Alain</dc:creator>
    <dc:contributor>Shakra, Malak Abu</dc:contributor>
    <dc:contributor>Pihl, Robert</dc:contributor>
    <dc:creator>Pruessner, Jens C.</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/4.0/"/>
    <dc:creator>Shakra, Malak Abu</dc:creator>
    <dc:creator>Pihl, Robert</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-01-25T09:53:37Z</dc:date>
    <dcterms:issued>2018-01</dcterms:issued>
    <dcterms:abstract xml:lang="eng">Background&lt;br /&gt;The delineation of the behavioral neurobiological mechanisms underlying the heterogeneous pathways for alcohol use disorders (AUDs) is ostensibly imperative for the development of more cost-effective treatments predicated on better understanding of this complex psychopathology.&lt;br /&gt;&lt;br /&gt;Methods&lt;br /&gt;1) Forty-eight high anxiety sensitive (HAS) and high sensation seeking (HSS) psychopathology-free emerging adults (mean (SD) age: 20.4 (1.9) years) completed a Face Emotion Processing Task and a social stress paradigm (Montreal Imaging Stress Task) during functional magnetic resonance imaging sessions with and without alcohol ingestion (1 ml/kg of 95% USP alcohol, p.o.). Drug and alcohol use was reassessed during follow-up interviews 2–3 years later.&lt;br /&gt;&lt;br /&gt;Outcomes&lt;br /&gt;The effects of alcohol (versus placebo) ingestion depended upon the task and risk group. In response to negative (versus neutral) faces, alcohol diminished amygdala (AMYG) activations in HAS but not HSS subjects. In response to psychosocial evaluative stress, alcohol enhanced activations of the medial orbitofrontal cortex (mOFC), perigenual anterior cingulate cortex, and nucleus accumbens in HAS male subjects (HASMS), but decreased mOFC activity in HSS male subjects (HSSMS). At follow-up, a greater alcohol versus placebo differential for threat-related AMYG activations predicted escalating drinking and/or illicit drug use among HAS but not HSS participants, whereas a greater differential for mOFC activations during acute social stress predicted escalating substance use among HSS but not HAS participants.&lt;br /&gt;&lt;br /&gt;Interpretation&lt;br /&gt;This double dissociation provides evidence of distinct neurobiological profiles in a priori identified personality trait-based risk groups for AUDs, and links these signatures to clinically relevant substance use outcomes at follow-up. AUD subtypes might benefit from motivationally and personality-specific ameliorative and preventative interventions.</dcterms:abstract>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:language>eng</dc:language>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/41152/1/Shakra_2-4rhn6lv82sut7.pdf"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Moghnieh, Hussein</dc:creator>
    <dc:contributor>Leyton, Marco</dc:contributor>
    <dc:contributor>Moghnieh, Hussein</dc:contributor>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dc:contributor>Dagher, Alain</dc:contributor>
    <dcterms:title>Neurobiological Correlates and Predictors of Two Distinct Personality Trait Pathways to Escalated Alcohol Use</dcterms:title>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Ja
Diese Publikation teilen