The role of norepinephrine and alpha-adrenergic receptors in acute stress-induced changes in granulocytes and monocytes

Beis, Daniel; von Känel, Roland; Heimgartner, Nadja; Zuccarella-Hackl, Claudia; Bürkle, Alexander; Ehlert, Ulrike; Wirtz, Petra H.

The role of norepinephrine and alpha-adrenergic receptors in acute stress-induced changes in granulocytes and monocytes

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Datum

2018

Autor:innen

Beis, Daniel

von Känel, Roland

Heimgartner, Nadja

Zuccarella-Hackl, Claudia

Bürkle, Alexander

Ehlert, Ulrike

Wirtz, Petra H.

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Psychologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Psychosomatic medicine. 2018, 80(7), pp. 649-658. ISSN 0033-3174. eISSN 1534-7796. Available under: doi: 10.1097/PSY.0000000000000620

Zusammenfassung

Objective Acute stress induces redistribution of circulating leucocytes in humans. Whereas effects on lymphocytes as adaptive immune cells are well-understood, the mechanisms underlying stress effects on granulocytes and monocytes as innate immune blood cells are still elusive. We investigated whether the stress hormone norepinephrine (NE) and α-adrenergic receptors (α-ADRs) may play a mediating role.
Methods In a stress study, we cross-sectionally tested in 44 healthy men for associations between stress-induced NE increases and simultaneous granulocyte and monocyte cell count increases, as measured immediately before and several times after the Trier Social Stress Test. In a subsequent infusion study, 21 healthy men participated in three different experimental trials with sequential infusions of 1 and 15-min duration with varying substances [saline as placebo, the non-specific α-ADR blocker phentolamine (2.5mg/min), and NE (5μg/min)]: trial1=saline+saline, trial2=saline+NE, trial3=phentolamine+NE. Granulocyte and monocyte cell numbers were assessed before, immediately after, 10min, and 30min after infusion procedures.
Results In the stress study, higher NE related to higher neutrophil stress changes (β=.31,p=.045, R2change=.09), but not epinephrine stress changes. In the infusion study, saline+NE induced significant increases in neutrophil (F(3/60)=43.50,p<.001,η²=.69) and monocyte (F(3/60)=18.56,p<.001,η sup>2=.48) numbers compared to saline+saline. With phentolamine+NE, neutrophil (F(3/60)=14.41,p<.001,η²=.42) and monocyte counts (F(2.23/44.6)=4.32,p=.016,η²=.18) remained increased compared to saline+saline but were lower compared to saline+NE (neutrophils: F(3/60)=19.55,p<.001,η ²=.494, monocytes: F(3/60)=2.54,p=.065,η²=.11) indicating partial mediation by α-ADRs. Trials did not differ in eosinophil and basophil count reactivity.
Conclusions Our findings suggest that NE-induced immediate increases in neutrophil and monocyte numbers resemble psychosocial stress effects and can be reduced by blockade of α-ADRs.

Fachgebiet (DDC)

150 Psychologie

Schlagwörter

granulocytes, monocytes, norepinephrine, phentolamine, alpha-adrenergic receptor blocker, stress

Zitieren

ISO 690

BEIS, Daniel, Roland VON KÄNEL, Nadja HEIMGARTNER, Claudia ZUCCARELLA-HACKL, Alexander BÜRKLE, Ulrike EHLERT, Petra H. WIRTZ, 2018. The role of norepinephrine and alpha-adrenergic receptors in acute stress-induced changes in granulocytes and monocytes. In: Psychosomatic medicine. 2018, 80(7), pp. 649-658. ISSN 0033-3174. eISSN 1534-7796. Available under: doi: 10.1097/PSY.0000000000000620

BibTex

@article{Beis2018-09norep-42868,
  year={2018},
  doi={10.1097/PSY.0000000000000620},
  title={The role of norepinephrine and alpha-adrenergic receptors in acute stress-induced changes in granulocytes and monocytes},
  number={7},
  volume={80},
  issn={0033-3174},
  journal={Psychosomatic medicine},
  pages={649--658},
  author={Beis, Daniel and von Känel, Roland and Heimgartner, Nadja and Zuccarella-Hackl, Claudia and Bürkle, Alexander and Ehlert, Ulrike and Wirtz, Petra H.}
}

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    <dcterms:abstract xml:lang="eng">Objective Acute stress induces redistribution of circulating leucocytes in humans. Whereas effects on lymphocytes as adaptive immune cells are well-understood, the mechanisms underlying stress effects on granulocytes and monocytes as innate immune blood cells are still elusive. We investigated whether the stress hormone norepinephrine (NE) and α-adrenergic receptors (α-ADRs) may play a mediating role.&lt;br /&gt;Methods In a stress study, we cross-sectionally tested in 44 healthy men for associations between stress-induced NE increases and simultaneous granulocyte and monocyte cell count increases, as measured immediately before and several times after the Trier Social Stress Test. In a subsequent infusion study, 21 healthy men participated in three different experimental trials with sequential infusions of 1 and 15-min duration with varying substances [saline as placebo, the non-specific α-ADR blocker phentolamine (2.5mg/min), and NE (5μg/min)]: trial1=saline+saline, trial2=saline+NE, trial3=phentolamine+NE. Granulocyte and monocyte cell numbers were assessed before, immediately after, 10min, and 30min after infusion procedures.&lt;br /&gt;Results In the stress study, higher NE related to higher neutrophil stress changes (β=.31,p=.045, R2change=.09), but not epinephrine stress changes. In the infusion study, saline+NE induced significant increases in neutrophil (F(3/60)=43.50,p&lt;.001,η&lt;sup&gt;2&lt;/sup&gt;=.69) and monocyte (F(3/60)=18.56,p&lt;.001,η sup&gt;2&lt;/sup&gt;=.48) numbers compared to saline+saline. With phentolamine+NE, neutrophil (F(3/60)=14.41,p&lt;.001,η&lt;sup&gt;2&lt;/sup&gt;=.42) and monocyte counts (F(2.23/44.6)=4.32,p=.016,η&lt;sup&gt;2&lt;/sup&gt;=.18) remained increased compared to saline+saline but were lower compared to saline+NE (neutrophils: F(3/60)=19.55,p&lt;.001,η &lt;sup&gt;2&lt;/sup&gt;=.494, monocytes: F(3/60)=2.54,p=.065,η&lt;sup&gt;2&lt;/sup&gt;=.11) indicating partial mediation by α-ADRs. Trials did not differ in eosinophil and basophil count reactivity.&lt;br /&gt;Conclusions Our findings suggest that NE-induced immediate increases in neutrophil and monocyte numbers resemble psychosocial stress effects and can be reduced by blockade of α-ADRs.</dcterms:abstract>
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