@article{Schmidt2019-09Nucle-45215,
  year={2019},
  doi={10.1007/s00406-018-0947-6},
  title={Nucleus accumbens activation is linked to salience in social decision making},
  number={6},
  volume={269},
  issn={0940-1334},
  journal={European archives of psychiatry and clinical neuroscience},
  pages={701--712},
  author={Schmidt, Stephanie N. L. and Fenske, Sabrina C. and Kirsch, Peter and Mier, Daniela}
}

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    <dc:creator>Mier, Daniela</dc:creator>
    <dc:contributor>Mier, Daniela</dc:contributor>
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    <dcterms:title>Nucleus accumbens activation is linked to salience in social decision making</dcterms:title>
    <dc:creator>Fenske, Sabrina C.</dc:creator>
    <dc:creator>Kirsch, Peter</dc:creator>
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    <dc:contributor>Fenske, Sabrina C.</dc:contributor>
    <dc:contributor>Schmidt, Stephanie N. L.</dc:contributor>
    <dc:creator>Schmidt, Stephanie N. L.</dc:creator>
    <dcterms:abstract xml:lang="eng">Aberrant salience may explain hasty decision making and psychotic symptoms in schizophrenia. In healthy individuals, final decisions in probabilistic reasoning tasks are related to Nucleus accumbens (Nacc) activation. However, research investigating the Nacc in social decision making is missing. Our study aimed at investigating the role of the Nacc for social decision making and its link to (aberrant) salience attribution. 47 healthy individuals completed a novel social jumping-to-conclusion (JTC) fMRI-paradigm, showing morphed faces simultaneously expressing fear and happiness. Participants decided on the 'current' emotion after each picture, and on the 'general' emotion of series of faces. Nacc activation was stronger during final decisions than in previous trials without a decision, particularly in fear rather than happiness series. A JTC-bias was associated with higher Nacc activation for last fearful, but not last happy faces. Apparently, mechanisms underlying probabilistic reasoning are also relevant for social decision making. The pattern of Nacc activation suggests salience, not reward, drives the final decision. Based on these findings, we hypothesize that aberrant salience might also explain social-cognitive deficits in schizophrenia.</dcterms:abstract>
    <dc:language>eng</dc:language>
    <dcterms:issued>2019-09</dcterms:issued>
    <dc:contributor>Kirsch, Peter</dc:contributor>
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