Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase

Betz, Karin; Nilforoushan, Arman; Wyss, Laura A.; Diederichs, Kay; Sturla, Shana J.; Marx, Andreas

Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase

Dateien

Betz_2-emplm7zacqca1.pdfGröße: 195.17 KBDownloads: 207

Datum

2017

Autor:innen

Betz, Karin

Nilforoushan, Arman

Wyss, Laura A.

Diederichs, Kay

Sturla, Shana J.

Marx, Andreas

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Chemie
Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Chemical Communications : ChemComm. 2017, 53(94), pp. 12704-12707. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/c7cc07173f

Zusammenfassung

The possibility to sequence cytotoxic O⁶-alkylG DNA adducts would greatly benefit research. Recently we reported a benzimidazole-derived nucleotide that is selectively incorporated opposite the damaged site by a mutated DNA polymerase. Here we provide the structural basis for this reaction which may spur future developments in DNA damage sequencing.

Fachgebiet (DDC)

540 Chemie

Zitieren

ISO 690

BETZ, Karin, Arman NILFOROUSHAN, Laura A. WYSS, Kay DIEDERICHS, Shana J. STURLA, Andreas MARX, 2017. Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase. In: Chemical Communications : ChemComm. 2017, 53(94), pp. 12704-12707. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/c7cc07173f

BibTex

@article{Betz2017-11-23Struc-40878,
  year={2017},
  doi={10.1039/c7cc07173f},
  title={Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase},
  number={94},
  volume={53},
  issn={1359-7345},
  journal={Chemical Communications : ChemComm},
  pages={12704--12707},
  author={Betz, Karin and Nilforoushan, Arman and Wyss, Laura A. and Diederichs, Kay and Sturla, Shana J. and Marx, Andreas}
}

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Universitätsbibliographie

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