Neuronal correlates of affective theory of mind in schizophrenia out-patients : evidence for a baseline deficit

Mier, Daniela; Sauer, Carina; Lis, Stefanie; Esslinger, Christine; Wilhelm, Johannes; Gallhofer, Bernd; Kirsch, Peter

Neuronal correlates of affective theory of mind in schizophrenia out-patients : evidence for a baseline deficit

Dateien

Mier_2-iqj4omlx80tc7.pdfGröße: 170.37 KBDownloads: 504

Datum

2010

Autor:innen

Mier, Daniela

Sauer, Carina

Lis, Stefanie

Esslinger, Christine

Wilhelm, Johannes

Gallhofer, Bernd

Kirsch, Peter

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Psychologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Psychological Medicine. 2010, 40(10), pp. 1607-1617. ISSN 0033-2917. eISSN 1469-8978. Available under: doi: 10.1017/S0033291709992133

Zusammenfassung

Background:
Schizophrenia out-patients have deficits in affective theory of mind (ToM) but also on more basal levels of social cognition, such as the processing of neutral and emotional expressions. These deficits are associated with changes in brain activation in the amygdala and the superior temporal sulcus (STS). However, until now there have been no studies that examined these different levels of social cognition and their neurobiological underpinnings in patients within one design.

Method:
Sixteen medicated schizophrenia out-patients and 16 matched healthy controls were studied with functional magnetic resonance imaging (fMRI) during a social cognition task that allows the investigation of affective ToM (aToM), emotion recognition and the processing of neutral facial expressions.

Results:
Patients showed a deficit in emotion recognition and a more prominent deficit in aToM. The performance in aToM and in emotion recognition was correlated in the control group but not in the schizophrenia group. Region-of-interest analysis of functional brain imaging data revealed no difference between groups during aToM, but a hyperactivation in the schizophrenia group in the left amygdala and right STS during emotion recognition and the processing of neutral facial expressions.

Conclusions:
The results indicate that schizophrenia out-patients have deficits at several levels of social cognition and provide the first evidence that deficits on higher-order social cognitive processes in schizophrenia may be traced back to an aberrant processing of faces per se.

Fachgebiet (DDC)

150 Psychologie

Schlagwörter

Emotion recognition, fMRI, schizophrenia, social cognition, theory of mind

Zitieren

ISO 690

MIER, Daniela, Carina SAUER, Stefanie LIS, Christine ESSLINGER, Johannes WILHELM, Bernd GALLHOFER, Peter KIRSCH, 2010. Neuronal correlates of affective theory of mind in schizophrenia out-patients : evidence for a baseline deficit. In: Psychological Medicine. 2010, 40(10), pp. 1607-1617. ISSN 0033-2917. eISSN 1469-8978. Available under: doi: 10.1017/S0033291709992133

BibTex

@article{Mier2010-10Neuro-45708,
  year={2010},
  doi={10.1017/S0033291709992133},
  title={Neuronal correlates of affective theory of mind in schizophrenia out-patients : evidence for a baseline deficit},
  number={10},
  volume={40},
  issn={0033-2917},
  journal={Psychological Medicine},
  pages={1607--1617},
  author={Mier, Daniela and Sauer, Carina and Lis, Stefanie and Esslinger, Christine and Wilhelm, Johannes and Gallhofer, Bernd and Kirsch, Peter}
}

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Universitätsbibliographie

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Begutachtet

Ja