@article{Vikhreva2017TAp73-56687,
  year={2017},
  doi={10.1016/j.bbrc.2016.10.085},
  title={TAp73 upregulates IL-1β in cancer cells : Potential biomarker in lung and breast cancer?},
  number={3},
  volume={482},
  issn={0006-291X},
  journal={Biochemical and Biophysical Research Communications (BBRC)},
  pages={498--505},
  author={Vikhreva, Polina and Petrova, Varvara and Gokbulut, Tarik and Pestlikis, Ilias and Mancini, Mara and Di Daniele, Nicola and Knight, Richard A. and Melino, Gerry and Amelio, Ivano}
}

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/56687">
    <dc:contributor>Gokbulut, Tarik</dc:contributor>
    <dc:creator>Gokbulut, Tarik</dc:creator>
    <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 International</dc:rights>
    <dcterms:abstract xml:lang="eng">p73 is a transcription factor belonging to the p53 tumour suppressor family. p73-/- mice exhibit a range of phenotypes including neurological, reproductive and inflammatory defects. Although the role of p73 in the control of genomic stability explains part of these phenotypes, a clear mechanism of how p73 participates in the inflammatory response is still elusive. Interleukin-1β (IL-1β) has a crucial role in mediating the inflammatory response. Because of its high potency to induce inflammation, the activation and secretion of IL-1β is tightly regulated by large protein complexes, named inflammasomes. Inflammasomes regulate activation of proinflammatory caspase-1, which in turn proteolytically processes its substrates, including pro-IL-1β. Caspase-1 gene transcription is strongly activated by p53 protein family members including p73. Here, we have addressed whether p73 might be directly involved in IL-1β regulation and therefore in the control of the inflammatory response. Our results show that TAp73β upregulates pro-IL-1β mRNA and processed IL-1β protein. In addition, analysis of breast and lung cancer patient cohorts demonstrated that interaction between p73 and IL-1β predicts a negative survival outcome in these human cancers.</dcterms:abstract>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-02-25T08:48:40Z</dc:date>
    <dc:creator>Melino, Gerry</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-02-25T08:48:40Z</dcterms:available>
    <dc:contributor>Knight, Richard A.</dc:contributor>
    <dc:creator>Di Daniele, Nicola</dc:creator>
    <dc:contributor>Vikhreva, Polina</dc:contributor>
    <dc:contributor>Petrova, Varvara</dc:contributor>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Melino, Gerry</dc:contributor>
    <dc:creator>Amelio, Ivano</dc:creator>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Petrova, Varvara</dc:creator>
    <dc:language>eng</dc:language>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/56687/1/Vikhreva_2-l3e3yo36c2s09.pdf"/>
    <dc:contributor>Di Daniele, Nicola</dc:contributor>
    <dcterms:title>TAp73 upregulates IL-1β in cancer cells : Potential biomarker in lung and breast cancer?</dcterms:title>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/56687"/>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/4.0/"/>
    <dcterms:issued>2017</dcterms:issued>
    <dc:contributor>Mancini, Mara</dc:contributor>
    <dc:creator>Vikhreva, Polina</dc:creator>
    <dc:contributor>Amelio, Ivano</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/56687/1/Vikhreva_2-l3e3yo36c2s09.pdf"/>
    <dc:creator>Mancini, Mara</dc:creator>
    <dc:creator>Knight, Richard A.</dc:creator>
    <dc:creator>Pestlikis, Ilias</dc:creator>
    <dc:contributor>Pestlikis, Ilias</dc:contributor>
  </rdf:Description>
</rdf:RDF>