@article{Winzeler2017-03-04Adver-39123,
  year={2017},
  doi={10.1080/10615806.2016.1238076},
  title={Adverse childhood experiences and autonomic regulation in response to acute stress : the role of the sympathetic and parasympathetic nervous systems},
  number={2},
  volume={30},
  issn={1061-5806},
  journal={Anxiety, Stress, & Coping},
  pages={145--154},
  author={Winzeler, Katja and Voellmin, Annette and Hug, Evelin and Kirmse, Ursula and Helmig, Simone and Princip, Mary and Cajochen, Christian and Bader, Klaus and Wilhelm, Frank H.}
}

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    <dc:creator>Winzeler, Katja</dc:creator>
    <dc:contributor>Winzeler, Katja</dc:contributor>
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    <dcterms:title>Adverse childhood experiences and autonomic regulation in response to acute stress : the role of the sympathetic and parasympathetic nervous systems</dcterms:title>
    <dc:contributor>Hug, Evelin</dc:contributor>
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    <dc:creator>Helmig, Simone</dc:creator>
    <dc:contributor>Cajochen, Christian</dc:contributor>
    <dc:contributor>Wilhelm, Frank H.</dc:contributor>
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    <dc:contributor>Voellmin, Annette</dc:contributor>
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    <dc:creator>Voellmin, Annette</dc:creator>
    <dc:contributor>Bader, Klaus</dc:contributor>
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    <dc:creator>Wilhelm, Frank H.</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-06-06T09:09:35Z</dc:date>
    <dc:contributor>Princip, Mary</dc:contributor>
    <dc:creator>Bader, Klaus</dc:creator>
    <dc:creator>Hug, Evelin</dc:creator>
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    <dc:contributor>Kirmse, Ursula</dc:contributor>
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    <dc:creator>Cajochen, Christian</dc:creator>
    <dc:creator>Princip, Mary</dc:creator>
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    <dc:contributor>Helmig, Simone</dc:contributor>
    <dcterms:abstract xml:lang="eng">Background and objectives: After a previous report demonstrated blunted heart rate (HR) reactivity in association with adverse childhood experiences (ACEs) [Voellmin, A., Winzeler, K., Hug, E., Wilhelm, F. H., Schaefer, V., Gaab, J., … Bader, K. (2015). Blunted endocrine and cardiovascular reactivity in young healthy women reporting a history of childhood adversity. Psychoneuroendocrinology, 51, 58–67. doi:10.1016/j.psyneuen.2014.09.008], the present analysis aimed at clarifying the role of the sympathetic and parasympathetic branches of the autonomic nervous system in this relationship.&lt;br /&gt;&lt;br /&gt;Design and Methods: One hundred eighteen healthy young women provided data on ACEs and underwent psychosocial stress testing. Systolic blood pressure (SBP) and respiratory sinus arrhythmia (RSA, quantified by high-frequency HR variability) were assessed as measures of sympathetic and parasympathetic cardiovascular activity, respectively. A mediation model was calculated to test the indirect effects of ACEs on HR via SBP and RSA.&lt;br /&gt;&lt;br /&gt;Results: The effect of ACEs on HR reactivity was mediated by SBP reactivity but not by RSA reactivity. ACEs were associated with reduced SBP at rest.&lt;br /&gt;&lt;br /&gt;Conclusions: ACEs were associated with down-regulation in a measure of sympathetic but no alteration in a measure of parasympathetic cardiovascular stress reactivity in adulthood. Future research will need to clarify whether this indicates risk or resilience.</dcterms:abstract>
    <dc:creator>Kirmse, Ursula</dc:creator>
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