@article{Rossy2012integ-43159,
  year={2012},
  doi={10.3389/fimmu.2012.00352},
  title={The integration of signaling and the spatial organization of the T cell synapse},
  volume={3},
  journal={Frontiers in Immunology},
  author={Rossy, Jérémie and Williamson, David J. and Benzing, Carola and Gaus, Katharina},
  note={Article Number: 352}
}

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    <dcterms:title>The integration of signaling and the spatial organization of the T cell synapse</dcterms:title>
    <dcterms:abstract xml:lang="eng">Engagement of the T cell antigen receptor (TCR) triggers signaling pathways that lead to T cell selection, differentiation and clonal expansion. Superimposed onto the biochemical network is a spatial organization that describes individual receptor molecules, dimers, oligomers and higher order structures. Here we discuss recent findings and new concepts that may regulate TCR organization in naïve and memory T cells. A key question that has emerged is how antigen-TCR interactions encode spatial information to direct T cell activation and differentiation. Single molecule super-resolution microscopy may become an important tool in decoding receptor organization at the molecular level.</dcterms:abstract>
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    <dc:contributor>Benzing, Carola</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-08-30T14:10:50Z</dc:date>
    <dc:creator>Rossy, Jérémie</dc:creator>
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    <dc:contributor>Rossy, Jérémie</dc:contributor>
    <dc:contributor>Williamson, David J.</dc:contributor>
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    <dc:creator>Williamson, David J.</dc:creator>
    <dc:contributor>Gaus, Katharina</dc:contributor>
    <dc:creator>Gaus, Katharina</dc:creator>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/43159"/>
    <dc:creator>Benzing, Carola</dc:creator>
    <dcterms:issued>2012</dcterms:issued>
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