@article{Redpath2019-09-26Floti-47518,
  year={2019},
  doi={10.1038/s41467-019-12352-w},
  title={Flotillins promote T cell receptor sorting through a fast Rab5-Rab11 endocytic recycling axis},
  number={1},
  volume={10},
  journal={Nature communications},
  author={Redpath, Gregory M. I. and Ecker, Manuela and Kapoor-Kaushik, Natasha and Vartoukian, Haig and Carnell, Michael and Kempe, Daryan and Biro, Maté and Ariotti, Nicholas and Rossy, Jérémie},
  note={Article Number: 4392}
}

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    <dc:creator>Ecker, Manuela</dc:creator>
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    <dc:creator>Rossy, Jérémie</dc:creator>
    <dc:contributor>Vartoukian, Haig</dc:contributor>
    <dc:contributor>Kapoor-Kaushik, Natasha</dc:contributor>
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    <dc:creator>Carnell, Michael</dc:creator>
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    <dc:contributor>Rossy, Jérémie</dc:contributor>
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    <dc:contributor>Redpath, Gregory M. I.</dc:contributor>
    <dc:contributor>Carnell, Michael</dc:contributor>
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    <dc:contributor>Kempe, Daryan</dc:contributor>
    <dcterms:abstract xml:lang="eng">The targeted endocytic recycling of the T cell receptor (TCR) to the immunological synapse is essential for T cell activation. Despite this, the mechanisms that underlie the sorting of internalised receptors into recycling endosomes remain poorly understood. To build a comprehensive picture of TCR recycling during T cell activation, we developed a suite of new imaging and quantification tools centred on photoactivation of fluorescent proteins. We show that the membrane-organising proteins, flotillin-1 and -2, are required for TCR to reach Rab5-positive endosomes immediately after endocytosis and for transfer from Rab5- to Rab11a-positive compartments. We further observe that after sorting into in Rab11a-positive vesicles, TCR recycles to the plasma membrane independent of flotillin expression. Our data suggest a mechanism whereby flotillins delineate a fast Rab5-Rab11a endocytic recycling axis and functionally contribute to regulate the spatial organisation of these endosomes.</dcterms:abstract>
    <dcterms:title>Flotillins promote T cell receptor sorting through a fast Rab5-Rab11 endocytic recycling axis</dcterms:title>
    <dc:creator>Kempe, Daryan</dc:creator>
    <dc:creator>Ariotti, Nicholas</dc:creator>
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    <dcterms:issued>2019-09-26</dcterms:issued>
    <dc:contributor>Biro, Maté</dc:contributor>
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    <dc:contributor>Ariotti, Nicholas</dc:contributor>
    <dc:creator>Kapoor-Kaushik, Natasha</dc:creator>
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    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-11-15T14:16:02Z</dc:date>
    <dc:creator>Biro, Maté</dc:creator>
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