Epigenetic and redox biomarkers : Novel insights from the MARK-AGE study

Moreno-Villanueva, Maria; Bürkle, Alexander

Epigenetic and redox biomarkers : Novel insights from the MARK-AGE study

Dateien

Moreno_2-mrn2222q9u976.pdfGröße: 93.47 KBDownloads: 703

Datum

2019

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Mechanisms of Ageing and Development. 2019, 177, pp. 128-134. ISSN 0047-6374. eISSN 1872-6216. Available under: doi: 10.1016/j.mad.2018.06.006

Zusammenfassung

Ageing is a multifactorial process that affects most, if not all, of the body’s tissues and organs and can be defined as the accumulation of physical and psychological changes in a human being over time. The rate of ageing differs between individuals of the same chronological age, meaning that ‘biological age’ of a person may be different from ‘chronological age’. Furthermore, ageing represents a very potent risk factor for diseases and disability in humans. Therefore, establishment of markers of biological ageing is important for preventing age-associated diseases and extending health span. MARK-AGE, a large-scale European study, aimed at identifying a set of biomarkers which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. But beyond the identification of useful biomarkers, MARK-AGE provided new insights in age-associated specific cellular processes, such as DNA methylation, oxidative stress and the regulation of zinc homeostasis.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

Human ageing, Biomarkers, Chronological age, Biological age, Health span, Observational study, Europe, Nutrition, Peripheral blood mononuclear cells, DNA damage, Epigenetics, Oxidative stress, Zinc homeostasis, DNA methyltransferases, en-eleven translocation family of 5-mC hydroxylases, Vaccination

Zitieren

ISO 690

MORENO-VILLANUEVA, Maria, Alexander BÜRKLE, 2019. Epigenetic and redox biomarkers : Novel insights from the MARK-AGE study. In: Mechanisms of Ageing and Development. 2019, 177, pp. 128-134. ISSN 0047-6374. eISSN 1872-6216. Available under: doi: 10.1016/j.mad.2018.06.006

BibTex

@article{MorenoVillanueva2019Epige-45053,
  year={2019},
  doi={10.1016/j.mad.2018.06.006},
  title={Epigenetic and redox biomarkers : Novel insights from the MARK-AGE study},
  volume={177},
  issn={0047-6374},
  journal={Mechanisms of Ageing and Development},
  pages={128--134},
  author={Moreno-Villanueva, Maria and Bürkle, Alexander}
}

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