@article{Prothiwa2021-05-26Inhib-53527,
  year={2021},
  doi={10.1039/d0sc06167k},
  title={Inhibiting quinolone biosynthesis of Burkholderia},
  number={20},
  volume={12},
  issn={2041-6520},
  journal={Chemical Science},
  pages={6908--6912},
  author={Prothiwa, Michaela and Filz, Verena and Oehler, Sebastian and Böttcher, Thomas}
}

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    <dc:creator>Oehler, Sebastian</dc:creator>
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    <dcterms:title>Inhibiting quinolone biosynthesis of Burkholderia</dcterms:title>
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    <dcterms:abstract xml:lang="eng">2-Alkylquinolones are important signalling molecules of Burkholderia species. We developed a substrate-based chemical probe against the central quinolone biosynthesis enzyme HmqD and applied it in competitive profiling experiments to discover the first known HmqD inhibitors. The most potent inhibitors quantitatively blocked quinolone production in Burkholderia cultures with single-digit micromolar efficacy.</dcterms:abstract>
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