Wide spectrum modulation by KP-544 in models relevant for neuronal survival

Geist, Marie A.; Volbracht, Christiane; Podhorna, Jana; Falsig, Jeppe; Leist, Marcel

Wide spectrum modulation by KP-544 in models relevant for neuronal survival

Dateien

Geist_2-z318drqouxnm1.pdfGröße: 414.85 KBDownloads: 591

Datum

2007

Autor:innen

Geist, Marie A.

Volbracht, Christiane

Podhorna, Jana

Falsig, Jeppe

Leist, Marcel

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Neuroreport. 2007, 18(6), pp. 571-575. ISSN 0959-4965. eISSN 1473-558X. Available under: doi: 10.1097/WNR.0b013e328012475c

Zusammenfassung

Reduced neurotrophic signalling has been proposed as a part of the pathophysiology behind neuronal death and dysfunction. The small molecule KP-544 was developed with the intention to enhance nerve growth factor signalling. To characterize the actions of KP-544 pharmacologically, we used four diverse models with relevance for neuronal function and survival. We found that 300-1000 nM KP-544 enhanced the neurite outgrowth in PC12 cells in response to a suboptimal concentration of nerve growth factor. KP-544 also protected the cerebellar granule cells from excitotoxicity apoptosis induced by the mitochondrial toxin methyl-phenyl-pyridinium, and modulated inflammation by inhibiting interleukin-6 production in primary astrocytes. Chronic treatment of rats with KP-544 prevented the hyper-responsiveness to amphetamine of animals treated with methylazoxymethanol acetate, a recently described neurodevelopmental model of schizophrenia.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

GEIST, Marie A., Christiane VOLBRACHT, Jana PODHORNA, Jeppe FALSIG, Marcel LEIST, 2007. Wide spectrum modulation by KP-544 in models relevant for neuronal survival. In: Neuroreport. 2007, 18(6), pp. 571-575. ISSN 0959-4965. eISSN 1473-558X. Available under: doi: 10.1097/WNR.0b013e328012475c

BibTex

@article{Geist2007-04-16spect-40776,
  year={2007},
  doi={10.1097/WNR.0b013e328012475c},
  title={Wide spectrum modulation by KP-544 in models relevant for neuronal survival},
  number={6},
  volume={18},
  issn={0959-4965},
  journal={Neuroreport},
  pages={571--575},
  author={Geist, Marie A. and Volbracht, Christiane and Podhorna, Jana and Falsig, Jeppe and Leist, Marcel}
}

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Universitätsbibliographie

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