Serine and glycine metabolism in cancer

Amelio, Ivano; Cutruzzolá, Francesca; Antonov, Alexey; Agostini, Massimiliano; Melino, Gerry

Serine and glycine metabolism in cancer

Dateien

Amelio_2-z3qkaotm878n6.pdfGröße: 419.21 KBDownloads: 90

Datum

2014

Autor:innen

Amelio, Ivano

Cutruzzolá, Francesca

Antonov, Alexey

Agostini, Massimiliano

Melino, Gerry

Open Access-Veröffentlichung

Open Access Hybrid

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Trends in biochemical sciences. Cell Press. 2014, 39(4), pp. 191-198. ISSN 0968-0004. eISSN 1362-4326. Available under: doi: 10.1016/j.tibs.2014.02.004

Zusammenfassung

Serine and glycine are biosynthetically linked, and together provide the essential precursors for the synthesis of proteins, nucleic acids, and lipids that are crucial to cancer cell growth. Moreover, serine/glycine biosynthesis also affects cellular antioxidative capacity, thus supporting tumour homeostasis. A crucial contribution of serine/glycine to cellular metabolism is through the glycine cleavage system, which refuels one-carbon metabolism; a complex cyclic metabolic network based on chemical reactions of folate compounds. The importance of serine/glycine metabolism is further highlighted by genetic and functional evidence indicating that hyperactivation of the serine/glycine biosynthetic pathway drives oncogenesis. Recent developments in our understanding of these pathways provide novel translational opportunities for drug development, dietary intervention, and biomarker identification of human cancers.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

cancer metabolism, serine, glycine, one-carbon metabolism, folate

Zitieren

ISO 690

AMELIO, Ivano, Francesca CUTRUZZOLÁ, Alexey ANTONOV, Massimiliano AGOSTINI, Gerry MELINO, 2014. Serine and glycine metabolism in cancer. In: Trends in biochemical sciences. Cell Press. 2014, 39(4), pp. 191-198. ISSN 0968-0004. eISSN 1362-4326. Available under: doi: 10.1016/j.tibs.2014.02.004

BibTex

@article{Amelio2014Serin-57085,
  year={2014},
  doi={10.1016/j.tibs.2014.02.004},
  title={Serine and glycine metabolism in cancer},
  number={4},
  volume={39},
  issn={0968-0004},
  journal={Trends in biochemical sciences},
  pages={191--198},
  author={Amelio, Ivano and Cutruzzolá, Francesca and Antonov, Alexey and Agostini, Massimiliano and Melino, Gerry}
}

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