How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism

Rossy, Jérémie; Williamson, David J.; Gaus, Katharina

How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism

Dateien

Rossy_2-z4r5kqx9fv5i6.pdfGröße: 1.89 MBDownloads: 226

Datum

2012

Autor:innen

Rossy, Jérémie

Williamson, David J.

Gaus, Katharina

Open Access-Veröffentlichung

Open Access Gold

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Frontiers in immunology. 2012, 3, 167. eISSN 1664-3224. Available under: doi: 10.3389/fimmu.2012.00167

Zusammenfassung

T cell signaling begins with the ligation of the T cell antigen receptor (TCR) by a cognate peptide and the phosphorylation of the receptor's immunoreceptor tyrosine-based activation motif domains by the kinase Lck. However, the canonical receptor model is insufficient to explain how the constitutively active kinase Lck can discriminate between non-ligated and ligated TCRs. Here, we discuss the factors that are thought to regulate the spatial distribution of the TCR and Lck, and therefore critically influence TCR signaling initiation.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

ROSSY, Jérémie, David J. WILLIAMSON, Katharina GAUS, 2012. How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism. In: Frontiers in immunology. 2012, 3, 167. eISSN 1664-3224. Available under: doi: 10.3389/fimmu.2012.00167

BibTex

@article{Rossy2012kinas-43470,
  year={2012},
  doi={10.3389/fimmu.2012.00167},
  title={How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism},
  volume={3},
  journal={Frontiers in immunology},
  author={Rossy, Jérémie and Williamson, David J. and Gaus, Katharina},
  note={Article Number: 167}
}

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Ja