@article{Halder2012Bisqu-20596,
  year={2012},
  doi={10.1186/1756-0500-5-138},
  title={Bisquinolinium compounds induce quadruplex-specific transcriptome changes in HeLa S3 cell lines},
  number={1},
  volume={5},
  issn={1756-0500},
  journal={BMC Research Notes},
  author={Halder, Rashi and Riou, Jean-Francois and Teulade-Fichou, Marie-Paule and Frickey, Tancred and Hartig, Jörg S.},
  note={Article Number: 138}
}

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    <dc:contributor>Halder, Rashi</dc:contributor>
    <dc:language>eng</dc:language>
    <dcterms:bibliographicCitation>BMC Research Notes ; 5 (2012). - 138</dcterms:bibliographicCitation>
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    <dc:creator>Halder, Rashi</dc:creator>
    <dc:rights>Attribution 2.0 Generic</dc:rights>
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    <dcterms:title>Bisquinolinium compounds induce quadruplex-specific transcriptome changes in HeLa S3 cell lines</dcterms:title>
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    <dc:creator>Hartig, Jörg S.</dc:creator>
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    <dcterms:abstract xml:lang="eng">Background&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;Guanosine rich sequences capable of forming G-quadruplex (G4) motifs are enriched near the gene transcription start site (TSS) in the human genome. When probed at the single gene level, G-quadruplex motifs residing in promoter regions show substantial effects on gene transcription. Moreover, further changes in transcription levels are noticed when G4-motifs are targeted with G-quadruplex-specific small molecules.&lt;br /&gt;&lt;br /&gt;Results&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;Global studies concerning general changes of the transcriptome via targeting promoter-based G-quadruplex motifs are very limited and have so far only been carried out with compounds displaying weak selectivity for quadruplex sequences. Here we utilize two G-quadruplex-specific bisquinolinium derivatives PhenDC3 and 360A and investigate their effects on the expression of the HeLa S3 transcriptome. Our results show wide-spread changes in the transcriptome with specificity for genes with G-quadruplex motifs near their transcription start sites (TSS). Using real-time PCR we further confirmed the specificity of PhenDC3 and 360A as potent molecules to target G-quadruplex-regulated genes.&lt;br /&gt;&lt;br /&gt;Conclusions&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;Specific effects on quadruplex-containing genes have been observed utilizing whole-transcriptome analysis upon treatment of cultured cells with quadruplex-selective bisquinolinium compounds.</dcterms:abstract>
    <dc:contributor>Hartig, Jörg S.</dc:contributor>
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    <dc:contributor>Frickey, Tancred</dc:contributor>
    <dc:creator>Riou, Jean-Francois</dc:creator>
    <dc:contributor>Riou, Jean-Francois</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-10-05T08:42:13Z</dc:date>
    <dcterms:issued>2012</dcterms:issued>
    <dc:creator>Teulade-Fichou, Marie-Paule</dc:creator>
    <dc:creator>Frickey, Tancred</dc:creator>
    <dc:contributor>Teulade-Fichou, Marie-Paule</dc:contributor>
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