Electrical Brain Stimulation Improves Cognitive Performance by Modulating Functional Connectivity and Task-Specific Activation

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2012
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Meinzer, Marcus
Antonenko, Daria
Lindenberg, Robert
Hetzer, Stefan
Ulm, Lena
Avirame, Keren
Flöel, Agnes
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Journal of Neuroscience. 2012, 32(5), pp. 1859-1866. ISSN 0270-6474. eISSN 1529-2401. Available under: doi: 10.1523/JNEUROSCI.4812-11.2012
Zusammenfassung

Excitatory anodal transcranial direct current stimulation (atDCS) can improve human cognitive functions, but neural underpinnings of its mode of action remain elusive. In a cross-over placebo ("sham") controlled study we used functional magnetic resonance imaging (fMRI) to investigate neurofunctional correlates of improved language functions induced by atDCS over a core language area, the left inferior frontal gyrus (IFG). Intrascanner transcranial direct current stimulation-induced changes in overt semantic word generation assessed behavioral modulation; task-related and task-independent (resting-state) fMRI characterized language network changes. Improved word-retrieval during atDCS was paralleled by selectively reduced task-related activation in the left ventral IFG, an area specifically implicated in semantic retrieval processes. Under atDCS, resting-state fMRI revealed increased connectivity of the left IFG and additional major hubs overlapping with the language network. In conclusion, atDCS modulates endogenous low-frequency oscillations in a distributed set of functionally connected brain areas, possibly inducing more efficient processing in critical task-relevant areas and improved behavioral performance.

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Fachgebiet (DDC)
150 Psychologie
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Electrical brain stimulation, cognitive performance, atDCS, fMRI
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ISO 690MEINZER, Marcus, Daria ANTONENKO, Robert LINDENBERG, Stefan HETZER, Lena ULM, Keren AVIRAME, Tobias FLAISCH, Agnes FLĂ–EL, 2012. Electrical Brain Stimulation Improves Cognitive Performance by Modulating Functional Connectivity and Task-Specific Activation. In: Journal of Neuroscience. 2012, 32(5), pp. 1859-1866. ISSN 0270-6474. eISSN 1529-2401. Available under: doi: 10.1523/JNEUROSCI.4812-11.2012
BibTex
@article{Meinzer2012-02-01Elect-21946,
  year={2012},
  doi={10.1523/JNEUROSCI.4812-11.2012},
  title={Electrical Brain Stimulation Improves Cognitive Performance by Modulating Functional Connectivity and Task-Specific Activation},
  number={5},
  volume={32},
  issn={0270-6474},
  journal={Journal of Neuroscience},
  pages={1859--1866},
  author={Meinzer, Marcus and Antonenko, Daria and Lindenberg, Robert and Hetzer, Stefan and Ulm, Lena and Avirame, Keren and Flaisch, Tobias and Flöel, Agnes}
}
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