@article{WaeckerleMen2005-09-01Dendr-22119,
  year={2005},
  doi={10.1002/pros.20231},
  title={Dendritic Cells Generated From Patients With Androgen-Independent Prostate Cancer Are Not Impaired in Migration and T-Cell Stimulation},
  number={4},
  volume={64},
  issn={0270-4137},
  journal={The Prostate},
  pages={323--331},
  author={Waeckerle-Men, Ying and Uetz-von Allmen, Edith and Moos, Roger von and Classon, Brendan J. and Scandella, Elke and Schmid, Hans-Peter and Ludewig, Burkhard and Gröttrup, Marcus and Gillessen, Silke}
}

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    <dc:creator>Ludewig, Burkhard</dc:creator>
    <dc:contributor>Gillessen, Silke</dc:contributor>
    <dc:contributor>Uetz-von Allmen, Edith</dc:contributor>
    <dcterms:issued>2005-09-01</dcterms:issued>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-02-26T08:57:04Z</dc:date>
    <dc:creator>Classon, Brendan J.</dc:creator>
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    <dc:creator>Scandella, Elke</dc:creator>
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    <dc:contributor>Gröttrup, Marcus</dc:contributor>
    <dc:creator>Moos, Roger von</dc:creator>
    <dc:contributor>Scandella, Elke</dc:contributor>
    <dc:creator>Waeckerle-Men, Ying</dc:creator>
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    <dc:contributor>Classon, Brendan J.</dc:contributor>
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    <dc:creator>Gröttrup, Marcus</dc:creator>
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    <dc:creator>Schmid, Hans-Peter</dc:creator>
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    <dc:contributor>Waeckerle-Men, Ying</dc:contributor>
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    <dcterms:abstract xml:lang="eng">BACKGROUND Dendritic cell (DC)-based vaccination has been investigated as immunotherapy for several types of cancer. A potential drawback to vaccination with autologous monocyte-derived DCs (MoDCs) could be that MoDCs from patients are functionally impaired. In case of androgen-independent prostate cancer (CaP), the cancer itself, diverse prior therapies, and the hormone manipulation may affect the immune system.&lt;br /&gt;&lt;br /&gt;METHODS. MoDCs from patients suffering from androgen-independent CaP were generated according to a clinically applicable protocol to evaluate the phenotype, maturation capacity, migration, and T-cell stimulation of these cells compared with those generated from tumor-free donors.&lt;br /&gt;&lt;br /&gt;RESULTS  MoDCs generated from CaP patients could be fully matured and efficiently migrated towards the chemokine CCL21. They had a strong potency to activate allogeneicCD4þ and CD8þ T-cells and to present antigens to specific CTL.&lt;br /&gt;&lt;br /&gt;CONCLUSIONS Our data suggest that MoDCs from patients with androgen-independent CaP are functionally intact and hence qualify as cellular vaccines for immunotherapy of advanced stage CaP.</dcterms:abstract>
    <dcterms:bibliographicCitation>The Prostate ; 64 (2005), 4. - S. 323-331</dcterms:bibliographicCitation>
    <dcterms:title>Dendritic Cells Generated From Patients With Androgen-Independent Prostate Cancer Are Not Impaired in Migration and T-Cell Stimulation</dcterms:title>
    <dc:contributor>Schmid, Hans-Peter</dc:contributor>
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    <dc:creator>Uetz-von Allmen, Edith</dc:creator>
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    <dc:creator>Gillessen, Silke</dc:creator>
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    <dc:contributor>Moos, Roger von</dc:contributor>
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