Expression of hepatitis C virus proteins does not interfere with major histocompatibility complex class I processing and presentation in vitro

Moradpour, Darius; Grabscheid, Benno; Kammer, Andreas R.; Schmidtke, Gunter; Gröttrup, Marcus; Blum, Hubert E.; Cerny, Andreas

Expression of hepatitis C virus proteins does not interfere with major histocompatibility complex class I processing and presentation in vitro

Dateien

Moradpour_221455.pdfGröße: 151.37 KBDownloads: 173

Datum

2001

Autor:innen

Moradpour, Darius

Grabscheid, Benno

Kammer, Andreas R.

Schmidtke, Gunter

Gröttrup, Marcus

Blum, Hubert E.

Cerny, Andreas

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Hepatology. 2001, 33(5), pp. 1282-1287. ISSN 0270-9139. eISSN 1527-3350. Available under: doi: 10.1053/jhep.2001.23793

Zusammenfassung

Hepatitis C virus (HCV) infection takes a chronic course in the majority of patients. The mechanisms underlying the evasion of the host immune response and viral persistence are poorly understood. In this context, we investigated interactions of HCV proteins with major histocompatibility complex (MHC) class I processing and presentation pathways using cell lines that allow the tetracycline-regulated expression of viral structural and nonstructural proteins. These well-characterized inducible cell lines were found to efficiently process and present endogenously synthesized HCV proteins via MHC class I. Functional MHC class I cell-surface expression and intracellular proteasome activity were not affected by the expression of HCV proteins. These results suggest that viral evasion of the host immune response does not involve interactions of HCV with MHC class I processing and presentation. Other mechanisms, such as interference with the interferon system, may be operative in HCV infection, leading to viral persistence.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

MORADPOUR, Darius, Benno GRABSCHEID, Andreas R. KAMMER, Gunter SCHMIDTKE, Marcus GRÖTTRUP, Hubert E. BLUM, Andreas CERNY, 2001. Expression of hepatitis C virus proteins does not interfere with major histocompatibility complex class I processing and presentation in vitro. In: Hepatology. 2001, 33(5), pp. 1282-1287. ISSN 0270-9139. eISSN 1527-3350. Available under: doi: 10.1053/jhep.2001.23793

BibTex

@article{Moradpour2001-05Expre-22145,
  year={2001},
  doi={10.1053/jhep.2001.23793},
  title={Expression of hepatitis C virus proteins does not interfere with major histocompatibility complex class I processing and presentation in vitro},
  number={5},
  volume={33},
  issn={0270-9139},
  journal={Hepatology},
  pages={1282--1287},
  author={Moradpour, Darius and Grabscheid, Benno and Kammer, Andreas R. and Schmidtke, Gunter and Gröttrup, Marcus and Blum, Hubert E. and Cerny, Andreas}
}

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