Fiber tractography based on diffusion tensor imaging compared with high-angular-resolution diffusion imaging with compressed sensing : initial experience

Kuhnt, Daniela; Bauer, Miriam H. A.; Egger, Jan; Richter, Mirco; Kapur, Tina; Sommer, Jens; Merhof, Dorit; Nimsky, Christopher

Fiber tractography based on diffusion tensor imaging compared with high-angular-resolution diffusion imaging with compressed sensing : initial experience

Dateien

Kuhnt_224287.pdfGröße: 9.57 MBDownloads: 1068

Datum

2013

Autor:innen

Kuhnt, Daniela

Bauer, Miriam H. A.

Egger, Jan

Richter, Mirco

Kapur, Tina

Sommer, Jens

Merhof, Dorit

Nimsky, Christopher

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Informatik und Informationswissenschaft

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Neurosurgery. 2013, 73(5), pp. E913-A175. ISSN 0148-396X. eISSN 1524-4040. Available under: doi: 10.1227/NEU.0b013e318270d9fb

Zusammenfassung

Background:

The most frequently used method for fiber tractography based on diffusion tensor imaging (DTI) is associated with restrictions in the resolution of crossing or kissing fibers and in the vicinity of tumor or edema. Tractography based on high-angular-resolution diffusion imaging (HARDI) is capable of overcoming this restriction. With compressed sensing (CS) techniques, HARDI acquisitions with a smaller number of directional measurements can be used, thus enabling the use of HARDI-based fiber tractography in clinical practice.

Objective:

To investigate whether HARDI+CS-based fiber tractography improves the display of neuroanatomically complex pathways and in areas of disturbed diffusion properties.

Methods:

Six patients with gliomas in the vicinity of language-related areas underwent 3-T magnetic resonance imaging including a diffusion-weighted data set with 30 gradient directions. Additionally, functional magnetic resonance imaging for cortical language sites was obtained. Fiber tractography was performed with deterministic streamline algorithms based on DTI using 3 different software platforms. Additionally, tractography based on reconstructed diffusion signals using HARDI+CS was performed.

Results:

HARDI+CS-based tractography displayed more compact fiber bundles compared with the DTI-based results in all cases. In 3 cases, neuroanatomically plausible fiber bundles were displayed in the vicinity of tumor and peritumoral edema, which could not be traced on the basis of DTI. The curvature around the sylvian fissure was displayed properly in 6 cases and in only 2 cases with DTI-based tractography.

Conclusion:

HARDI+CS seems to be a promising approach for fiber tractography in clinical practice for neuroanatomically complex fiber pathways and in areas of disturbed diffusion, overcoming the problem of long acquisition times.

Fachgebiet (DDC)

004 Informatik

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ISO 690

KUHNT, Daniela, Miriam H. A. BAUER, Jan EGGER, Mirco RICHTER, Tina KAPUR, Jens SOMMER, Dorit MERHOF, Christopher NIMSKY, 2013. Fiber tractography based on diffusion tensor imaging compared with high-angular-resolution diffusion imaging with compressed sensing : initial experience. In: Neurosurgery. 2013, 73(5), pp. E913-A175. ISSN 0148-396X. eISSN 1524-4040. Available under: doi: 10.1227/NEU.0b013e318270d9fb

BibTex

@article{Kuhnt2013-01Fiber-22428,
  year={2013},
  doi={10.1227/NEU.0b013e318270d9fb},
  title={Fiber tractography based on diffusion tensor imaging compared with high-angular-resolution diffusion imaging with compressed sensing : initial experience},
  number={5},
  volume={73},
  issn={0148-396X},
  journal={Neurosurgery},
  pages={E913--A175},
  author={Kuhnt, Daniela and Bauer, Miriam H. A. and Egger, Jan and Richter, Mirco and Kapur, Tina and Sommer, Jens and Merhof, Dorit and Nimsky, Christopher}
}

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