The African coelacanth genome provides insights into tetrapod evolution

Amemiya, Chris T.; Alföldi, Jessica; Lee, Alison P.; Fan, Shaohua; Manousaki, Tereza; Feiner, Nathalie; Kuraku, Shigehiro; Simakov, Oleg; Meyer, Axel; Lindblad-Toh, Kerstin

The African coelacanth genome provides insights into tetrapod evolution

Dateien

Amemyia_232889.pdfGröße: 731.49 KBDownloads: 326

Datum

2013

Autor:innen

Amemiya, Chris T.

Alföldi, Jessica

Lee, Alison P.

Simakov, Oleg

Lindblad-Toh, Kerstin

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Nature. 2013, 496(7445), pp. 311-316. ISSN 0028-0836. eISSN 1476-4687. Available under: doi: 10.1038/nature12027

Zusammenfassung

The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors provides a glimpse of the fish that first walked on land. Here we report the genome sequence of the African coelacanth, Latimeria chalumnae. Through a phylogenomic analysis, we conclude that the lungfish, and not the coelacanth, is the closest living relative of tetrapods. Coelacanth protein-coding genes are significantly more slowly evolving than those of tetrapods, unlike other genomic features. Analyses of changes in genes and regulatory elements during the vertebrate adaptation to land highlight genes involved in immunity, nitrogen excretion and the development of fins, tail, ear, eye, brain and olfaction. Functional assays of enhancers involved in the fin-to-limb transition and in the emergence of extra-embryonic tissues show the importance of the coelacanth genome as a blueprint for understanding tetrapod evolution.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

Genome evolution, Comperative genomics

Zitieren

ISO 690

AMEMIYA, Chris T., Jessica ALFÖLDI, Alison P. LEE, Shaohua FAN, Tereza MANOUSAKI, Nathalie FEINER, Shigehiro KURAKU, Oleg SIMAKOV, Axel MEYER, Kerstin LINDBLAD-TOH, 2013. The African coelacanth genome provides insights into tetrapod evolution. In: Nature. 2013, 496(7445), pp. 311-316. ISSN 0028-0836. eISSN 1476-4687. Available under: doi: 10.1038/nature12027

BibTex

@article{Amemiya2013-04-18Afric-23288,
  year={2013},
  doi={10.1038/nature12027},
  title={The African coelacanth genome provides insights into tetrapod evolution},
  number={7445},
  volume={496},
  issn={0028-0836},
  journal={Nature},
  pages={311--316},
  author={Amemiya, Chris T. and Alföldi, Jessica and Lee, Alison P. and Fan, Shaohua and Manousaki, Tereza and Feiner, Nathalie and Kuraku, Shigehiro and Simakov, Oleg and Meyer, Axel and Lindblad-Toh, Kerstin}
}

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Universitätsbibliographie

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