(4R)- and (4S)-fluoroproline in the conserved cis-prolyl peptide bond of the thioredoxin fold : tertiary structure context dictates ring puckering

Rubini, Marina; Schärer, Martin; Capitani, Guido; Glockshuber, Rudi

(4R)- and (4S)-fluoroproline in the conserved cis-prolyl peptide bond of the thioredoxin fold : tertiary structure context dictates ring puckering

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

2013

Autor:innen

Rubini, Marina

Schärer, Martin

Capitani, Guido

Glockshuber, Rudi

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

ChemBioChem. 2013, 14(9), pp. 1053-1057. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201300178

Zusammenfassung

Fine-tuning protein stability: The non-natural amino acids (2S,4R)- and (2S,4S)-fluoroproline modulate protein stability by biasing the proline ring pucker and the cis/trans equilibrium of prolyl peptide bonds. We incorporated both fluoroproline stereoisomers at the invariant cis-proline residue of the thioredoxin fold. The results show that tertiary structure context overrules the conformational preferences of fluoroprolines.

Fachgebiet (DDC)

540 Chemie

Schlagwörter

cis peptide bonds, fluoroprolines, proline ring puckers, protein engineering, protein structures

Zitieren

ISO 690

RUBINI, Marina, Martin SCHÄRER, Guido CAPITANI, Rudi GLOCKSHUBER, 2013. (4R)- and (4S)-fluoroproline in the conserved cis-prolyl peptide bond of the thioredoxin fold : tertiary structure context dictates ring puckering. In: ChemBioChem. 2013, 14(9), pp. 1053-1057. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201300178

BibTex

@article{Rubini2013-06-174Sflu-24514,
  year={2013},
  doi={10.1002/cbic.201300178},
  title={(4R)- and (4S)-fluoroproline in the conserved cis-prolyl peptide bond of the thioredoxin fold : tertiary structure context dictates ring puckering},
  number={9},
  volume={14},
  issn={1439-4227},
  journal={ChemBioChem},
  pages={1053--1057},
  author={Rubini, Marina and Schärer, Martin and Capitani, Guido and Glockshuber, Rudi}
}

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Universitätsbibliographie

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