@article{MorenoVillanueva2013Nglyc-25705,
  year={2013},
  doi={10.1038/tp.2013.93},
  title={N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder},
  number={10},
  volume={3},
  journal={Translational Psychiatry},
  author={Moreno-Villanueva, Maria and Morath, Julia and Vanhooren, Valerie and Elbert, Thomas and Kolassa, Stephan and Libert, Claude and Bürkle, Alexander and Kolassa, Iris-Tatjana},
  note={Article Number: e320}
}

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    <dcterms:title>N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder</dcterms:title>
    <dc:contributor>Bürkle, Alexander</dc:contributor>
    <dc:creator>Bürkle, Alexander</dc:creator>
    <dc:contributor>Kolassa, Iris-Tatjana</dc:contributor>
    <dc:contributor>Libert, Claude</dc:contributor>
    <dc:contributor>Elbert, Thomas</dc:contributor>
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    <dc:contributor>Moreno-Villanueva, Maria</dc:contributor>
    <dc:contributor>Kolassa, Stephan</dc:contributor>
    <dc:creator>Libert, Claude</dc:creator>
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    <dcterms:abstract xml:lang="eng">The prevalence of age-related diseases is increased in individuals with post-traumatic stress disorder (PTSD). However, the underlying biological mechanisms are still unclear. N-glycosylation is an age-dependent process, identified as a biomarker for physiological aging (GlycoAge Test). To investigate whether traumatic stress accelerates the aging process, we analyzed the N-glycosylation profile in n=13 individuals with PTSD, n=9 trauma-exposed individuals and in n=10 low-stress control subjects. Individuals with PTSD and trauma-exposed individuals presented an upward shift in the GlycoAge Test, equivalent to an advancement of the aging process by 15 additional years. Trauma-exposed individuals presented an intermediate N-glycosylation profile positioned between severely traumatized individuals with PTSD and low-stress control subjects. In conclusion, our data suggest that cumulative exposure to traumatic stressors accelerates the process of physiological aging.</dcterms:abstract>
    <dc:creator>Kolassa, Stephan</dc:creator>
    <dc:creator>Kolassa, Iris-Tatjana</dc:creator>
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    <dc:contributor>Morath, Julia</dc:contributor>
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    <dc:creator>Vanhooren, Valerie</dc:creator>
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