Local interneurons and projection neurons in the antennal lobe from a spiking point of view

Meyer, Anneke; Galizia, C. Giovanni; Nawrot, Martin Paul

Local interneurons and projection neurons in the antennal lobe from a spiking point of view

Dateien

Meyer_257585.pdfGröße: 657.85 KBDownloads: 668

Datum

2013

Autor:innen

Meyer, Anneke

Galizia, C. Giovanni

Nawrot, Martin Paul

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Journal of Neurophysiology. 2013, 110(10), pp. 2465-2474. ISSN 0022-3077. eISSN 1522-1598. Available under: doi: 10.1152/jn.00260.2013

Zusammenfassung

Local computation in microcircuits is an essential feature of distributed information processing in vertebrate and invertebrate brains. The insect antennal lobe represents a spatially confined local network that processes high-dimensional and redundant peripheral input to compute an efficient odor code. Social insects can rely on a particularly rich olfactory receptor repertoire, and they exhibit complex odor-guided behaviors. This corresponds with a high anatomical complexity of their antennal lobe network. In the honeybee, a large number of glomeruli that receive sensory input are interconnected by a dense network of local interneurons (LNs). Uniglomerular projection neurons (PNs) integrate sensory and recurrent local network input into an efficient spatio-temporal odor code. To investigate the specific computational roles of LNs and PNs, we measured several features of sub- and suprathreshold single-cell responses to in vivo odor stimulation. Using a semisupervised cluster analysis, we identified a combination of five characteristic features as sufficient to separate LNs and PNs from each other, independent of the applied odor-stimuli. The two clusters differed significantly in all these five features. PNs showed a higher spontaneous subthreshold activation, assumed higher peak response rates and a more regular spiking pattern. LNs reacted considerably faster to the onset of a stimulus, and their responses were more reliable across stimulus repetitions. We discuss possible mechanisms that can explain our results, and we interpret cell-type-specific characteristics with respect to their functional relevance.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

MEYER, Anneke, C. Giovanni GALIZIA, Martin Paul NAWROT, 2013. Local interneurons and projection neurons in the antennal lobe from a spiking point of view. In: Journal of Neurophysiology. 2013, 110(10), pp. 2465-2474. ISSN 0022-3077. eISSN 1522-1598. Available under: doi: 10.1152/jn.00260.2013

BibTex

@article{Meyer2013-11Local-25758,
  year={2013},
  doi={10.1152/jn.00260.2013},
  title={Local interneurons and projection neurons in the antennal lobe from a spiking point of view},
  number={10},
  volume={110},
  issn={0022-3077},
  journal={Journal of Neurophysiology},
  pages={2465--2474},
  author={Meyer, Anneke and Galizia, C. Giovanni and Nawrot, Martin Paul}
}

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