@article{Fellner2014-01Pheno-26227,
  year={2014},
  doi={10.1111/1574-6968.12288},
  title={Phenotype of htgA (mbiA), a recently evolved orphan gene of Escherichia coli and Shigella, completely overlapping in antisense to yaaW},
  number={1},
  volume={350},
  issn={0378-1097},
  journal={FEMS Microbiology Letters},
  pages={57--64},
  author={Fellner, Lea and Bechtel, Niklas and Witting, Michael A. and Simon, Svenja and Schmitt-Kopplin, Philippe and Keim, Daniel A. and Scherer, Siegfried and Neuhaus, Klaus}
}

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    <dc:creator>Bechtel, Niklas</dc:creator>
    <dcterms:bibliographicCitation>FEMS Microbiology Letters ; 350 (2014), 1. - S. 57-64</dcterms:bibliographicCitation>
    <dc:contributor>Simon, Svenja</dc:contributor>
    <dc:contributor>Scherer, Siegfried</dc:contributor>
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    <dcterms:title>Phenotype of htgA (mbiA), a recently evolved orphan gene of Escherichia coli and Shigella, completely overlapping in antisense to yaaW</dcterms:title>
    <dc:contributor>Schmitt-Kopplin, Philippe</dc:contributor>
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    <dc:creator>Neuhaus, Klaus</dc:creator>
    <dcterms:abstract xml:lang="eng">Overlapping embedded genes, such as htgA/yaaW, are assumed to be rare in prokaryotes. In Escherichia coli O157:H7, gfp fusions of both promoter regions revealed activity and transcription start sites could be determined for both genes. Both htgA and yaaW were inactivated strand specifically by introducing a stop codon. Both mutants exhibited differential phenotypes in biofilm formation and metabolite levels in a nontargeted analysis, suggesting that both are functional despite YaaW but not HtgA could be expressed. While yaaW is distributed all over the Gammaproteobacteria, an overlapping htgA-like sequence is restricted to the Escherichia-Klebsiella clade. Full-length htgA is only present in Escherichia and Shigella, and htgA showed evidence for purifying selection. Thus, htgA is an interesting case of a lineage-specific, nonessential and young orphan gene.</dcterms:abstract>
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    <dc:creator>Fellner, Lea</dc:creator>
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    <dc:contributor>Keim, Daniel A.</dc:contributor>
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    <dc:contributor>Neuhaus, Klaus</dc:contributor>
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