DNA Polymerase Selectivity : Sugar Interactions Monitored with High-Fidelity Nucleotides

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summererandmarx.pdf
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Angewandte Chemie International Edition. 2001, 40(19), pp. 3693-3695. ISSN 1433-7851. eISSN 1521-3773. Available under: doi: 10.1002/1521-3773(20011001)40:19<3693::AID-ANIE3693>3.0.CO;2-O
Zusammenfassung

Do enzyme sugar interactions contribute to DNA-polymerase fidelity? With the novel chemical probes 1 (R=CH3, CH2CH3, CH(CH3)2, CH2CH(CH3)2), which are used by a DNA polymerase more selectively than the natural counterpart (R=H), insights are obtained into the influence of enzyme sugar interactions on the selectivity of the enzyme.

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Fachgebiet (DDC)
540 Chemie
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bioorganic chemistry, DNA polymerases, DNA recognition, DNA replication, nucleotides
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ISO 690SUMMERER, Daniel, Andreas MARX, 2001. DNA Polymerase Selectivity : Sugar Interactions Monitored with High-Fidelity Nucleotides. In: Angewandte Chemie International Edition. 2001, 40(19), pp. 3693-3695. ISSN 1433-7851. eISSN 1521-3773. Available under: doi: 10.1002/1521-3773(20011001)40:19<3693::AID-ANIE3693>3.0.CO;2-O
BibTex
@article{Summerer2001Polym-9573,
  year={2001},
  doi={10.1002/1521-3773(20011001)40:19<3693::AID-ANIE3693>3.0.CO;2-O},
  title={DNA Polymerase Selectivity : Sugar Interactions Monitored with High-Fidelity Nucleotides},
  number={19},
  volume={40},
  issn={1433-7851},
  journal={Angewandte Chemie International Edition},
  pages={3693--3695},
  author={Summerer, Daniel and Marx, Andreas}
}
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