Differential Minor Groove Interactions between DNA Polymerase and Sugar Backbone of Primer and Template Strands

Summerer, Daniel; Marx, Andreas

Differential Minor Groove Interactions between DNA Polymerase and Sugar Backbone of Primer and Template Strands

Dateien

summerer4.pdfGröße: 172.46 KBDownloads: 325

Datum

2002

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Chemie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Journal of the American Chemical Society. 2002, 124(6), pp. 910-911. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/ja017244j

Zusammenfassung

DNA polymerases are the key enzymes for DNA synthesis involved in DNA replication, recombination, and repair. These enzymes undergo manifold contacts with the primer−template−substrates reaching up to several nucleotide pairs beyond the catalytic centre. To evaluate these enzyme contacts with the DNA substrates we applied novel synthetic steric probes in functional studies. We found that through application of the these probes valuable insights into DNA polymerase function can be gained, which might be useful for the design of new DNA polymerase-based nucleotide variation detection strategies.

Fachgebiet (DDC)

540 Chemie

Zitieren

ISO 690

SUMMERER, Daniel, Andreas MARX, 2002. Differential Minor Groove Interactions between DNA Polymerase and Sugar Backbone of Primer and Template Strands. In: Journal of the American Chemical Society. 2002, 124(6), pp. 910-911. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/ja017244j

BibTex

@article{Summerer2002Diffe-9906,
  year={2002},
  doi={10.1021/ja017244j},
  title={Differential Minor Groove Interactions between DNA Polymerase and Sugar Backbone of Primer and Template Strands},
  number={6},
  volume={124},
  issn={0002-7863},
  journal={Journal of the American Chemical Society},
  pages={910--911},
  author={Summerer, Daniel and Marx, Andreas}
}

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