Dimethyl titanocene Y : a valuable precursor for libraries of cytotoxic titanocene derivatives

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20_J.Inorg.Biochem.2010.pdf
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Journal of inorganic biochemistry. 2010, 104(8), pp. 863-867. ISSN 0162-0134. eISSN 1873-3344. Available under: doi: 10.1016/j.jinorgbio.2010.04.003
Zusammenfassung

Reaction of the known titanocene Y 2 with methyl lithium at -15 °C yields bis-[(p-methoxybenzyl)cyclopentadienyl]titanium(IV) dimethyl (dimethyl titanocene Y, 3), a hitherto unknown, surprisingly robust titanium (IV) dimethyl species. Dimethyl titanocene Y was utilized in the preparation of several bis-[(p-methoxybenzyl)cyclopentadienyl]titanium(IV) dicarboxylates by the reaction with the free carboxylic acids in fair to good yields. Cytotoxicity of all new compounds has been estimated in Hela S3 cells.

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Fachgebiet (DDC)
540 Chemie
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Cytotoxicity, Titanium complexes, Library-synthesis, Cancer
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ISO 690IMMEL, Timo, Josefine MARTIN, Christoph J. DÜRR, Ulrich GROTH, Thomas HUHN, 2010. Dimethyl titanocene Y : a valuable precursor for libraries of cytotoxic titanocene derivatives. In: Journal of inorganic biochemistry. 2010, 104(8), pp. 863-867. ISSN 0162-0134. eISSN 1873-3344. Available under: doi: 10.1016/j.jinorgbio.2010.04.003
BibTex
@article{Immel2010Dimet-10055,
  year={2010},
  doi={10.1016/j.jinorgbio.2010.04.003},
  title={Dimethyl titanocene Y : a valuable precursor for libraries of cytotoxic titanocene derivatives},
  number={8},
  volume={104},
  issn={0162-0134},
  journal={Journal of inorganic biochemistry},
  pages={863--867},
  author={Immel, Timo and Martin, Josefine and Dürr, Christoph J. and Groth, Ulrich and Huhn, Thomas}
}
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