MEG gamma band activity in schizophrenia patients and healthy subjects in a mental arithmetic task and at rest

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2000
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Clinical Neurophysiology. 2000, 111, pp. 2079-2087. Available under: doi: 10.1016/S1388-2457(00)00425-9
Zusammenfassung

Objectives: High frequency oscillations have been suggested as a correlate of cognitive processes and have recently also been implicated
in aberrant forms of information processing. The present study investigated whether magnetoencephalographic (MEG) gamma band activity
(20±71 Hz) can serve as an index of cognitive processes in the absence of external stimulation and to what extent gamma activity differs
between healthy people and schizophrenia patients.
Methods: The amount and topography of MEG power in the gamma band range was examined in 15 schizophrenia patients and 15 healthy
comparison subjects while performing a complex mental arithmetic task and at rest.
Results: In healthy subjects a left frontal and left fronto-temporal increase in gamma power was observed during mental arithmetic.
Schizophrenia patients either failed to display such a task effect (30±45 Hz) or had reversed lateralization with enhanced activity over right
frontal and right fronto-temporal regions under cognitive demands (45±71 Hz). In the frequency band from 60 to 71 Hz patients showed less
gamma at fronto-temporal, posterio-temporal and occipital sites irrespective of the task.
Conclusions: These results indicate, Ærst, that gamma topography can index cognitive activation in a very complex and purely internal
task. Second, groups differed in the pattern of activation during the task, a result which may be consistent with working memory dysfunction
in schizophrenia. Third, the general topographic difference between healthy subjects and patients is in line with the notion of abnormalities in
the thalamocortical circuit in schizophrenia.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
150 Psychologie
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MEG, Gamma band, Cognitive functioning, Schizophrenia
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ISO 690KISSLER, Johanna, Matthias M. MÜLLER, Thorsten FEHR, Brigitte ROCKSTROH, Thomas ELBERT, 2000. MEG gamma band activity in schizophrenia patients and healthy subjects in a mental arithmetic task and at rest. In: Clinical Neurophysiology. 2000, 111, pp. 2079-2087. Available under: doi: 10.1016/S1388-2457(00)00425-9
BibTex
@article{Kissler2000gamma-11197,
  year={2000},
  doi={10.1016/S1388-2457(00)00425-9},
  title={MEG gamma band activity in schizophrenia patients and healthy subjects in a mental arithmetic task and at rest},
  volume={111},
  journal={Clinical Neurophysiology},
  pages={2079--2087},
  author={Kissler, Johanna and Müller, Matthias M. and Fehr, Thorsten and Rockstroh, Brigitte and Elbert, Thomas}
}
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    <dcterms:abstract xml:lang="eng">Objectives: High frequency oscillations have been suggested as a correlate of cognitive processes and have recently also been implicated&lt;br /&gt;in aberrant forms of information processing. The present study investigated whether magnetoencephalographic (MEG) gamma band activity&lt;br /&gt;(20±71 Hz) can serve as an index of cognitive processes in the absence of external stimulation and to what extent gamma activity differs&lt;br /&gt;between healthy people and schizophrenia patients.&lt;br /&gt;Methods: The amount and topography of MEG power in the gamma band range was examined in 15 schizophrenia patients and 15 healthy&lt;br /&gt;comparison subjects while performing a complex mental arithmetic task and at rest.&lt;br /&gt;Results: In healthy subjects a left frontal and left fronto-temporal increase in gamma power was observed during mental arithmetic.&lt;br /&gt;Schizophrenia patients either failed to display such a task effect (30±45 Hz) or had reversed lateralization with enhanced activity over right&lt;br /&gt;frontal and right fronto-temporal regions under cognitive demands (45±71 Hz). In the frequency band from 60 to 71 Hz patients showed less&lt;br /&gt;gamma at fronto-temporal, posterio-temporal and occipital sites irrespective of the task.&lt;br /&gt;Conclusions: These results indicate, Ærst, that gamma topography can index cognitive activation in a very complex and purely internal&lt;br /&gt;task. Second, groups differed in the pattern of activation during the task, a result which may be consistent with working memory dysfunction&lt;br /&gt;in schizophrenia. Third, the general topographic difference between healthy subjects and patients is in line with the notion of abnormalities in&lt;br /&gt;the thalamocortical circuit in schizophrenia.</dcterms:abstract>
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