Retinal Axon Regeneration in the Lizard Gallotia galloti in the Presence of CNS Myelin and Oligodendrocytes

Lang, Dirk M.; Monzón-Mayor, Maximina; Bandtlow, Christine E.; Stürmer, Claudia

Retinal Axon Regeneration in the Lizard Gallotia galloti in the Presence of CNS Myelin and Oligodendrocytes

Dateien

Retinal_axon_regeneration.pdfGröße: 455.09 KBDownloads: 696

Datum

1998

Autor:innen

Lang, Dirk M.

Monzón-Mayor, Maximina

Bandtlow, Christine E.

Stürmer, Claudia

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

GLIA. 1998, 23(1), pp. 61-74. ISSN 0894-1491. eISSN 1098-1136. Available under: doi: 10.1002/(SICI)1098-1136(199805)23:1<61::AID-GLIA6>3.0.CO;2-7

Zusammenfassung

Retinal ganglion cell (RGC) axons in lizards (reptiles) were found to regenerate after optic nerve injury. To determine whether regeneration occurs because the visual pathway has growth-supporting glia cells or whether RGC axons regrow despite the presence of neurite growth-inhibitory components, the substrate properties of lizard optic nerve myelin and of oligodendrocytes were analyzed in vitro, using rat dorsal root ganglion (DRG) neurons. In addition, the response of lizard RGC axons upon contact with rat and reptilian oligodendrocytes or with myelin proteins from the mammalian central nervous system (CNS) was monitored. Lizard optic nerve myelin inhibited extension of rat DRG neurites, and lizard oligodendrocytes elicited DRG growth cone collapse. Both effects were partially reversed by antibody IN-1 against mammalian 35/250 kD neurite growth inhibitors, and IN-1 stained myelinated fiber tracts in the lizard CNS. However, lizard RGC growth cones grew freely across oligodendrocytes from the rat and the reptilian CNS. Mammalian CNS myelin proteins reconstituted into liposomes and added to elongating lizard RGC axons caused at most a transient collapse reaction. Growth cones always recovered within an hour and regrew. Thus, lizard CNS myelin and oligodendrocytes possess nonpermissive substrate properties for DRG neurons like corresponding structures and cells in the mammalian CNS, including mammalian-like neurite growth inhibitors. Lizard RGC axons, however, appear to be far less sensitive to these inhibitory substrate components and therefore may be able to regenerate through the visual pathway despite the presence of myelin and oligodendrocytes that block growth of DRG neurites.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

collapse assay, reptiles, neurite growth inhibitors

Zitieren

ISO 690

LANG, Dirk M., Maximina MONZÓN-MAYOR, Christine E. BANDTLOW, Claudia STÜRMER, 1998. Retinal Axon Regeneration in the Lizard Gallotia galloti in the Presence of CNS Myelin and Oligodendrocytes. In: GLIA. 1998, 23(1), pp. 61-74. ISSN 0894-1491. eISSN 1098-1136. Available under: doi: 10.1002/(SICI)1098-1136(199805)23:1<61::AID-GLIA6>3.0.CO;2-7

BibTex

@article{Lang1998Retin-6720,
  year={1998},
  doi={10.1002/(SICI)1098-1136(199805)23:1<61::AID-GLIA6>3.0.CO;2-7},
  title={Retinal Axon Regeneration in the Lizard Gallotia galloti in the Presence of CNS Myelin and Oligodendrocytes},
  number={1},
  volume={23},
  issn={0894-1491},
  journal={GLIA},
  pages={61--74},
  author={Lang, Dirk M. and Monzón-Mayor, Maximina and Bandtlow, Christine E. and Stürmer, Claudia}
}

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