Adaptive Plasticity of Xenopus Glial Cells In Vitro and After CNS Fiber Tract Lesions In Vivo

Lang, Dirk M.; Stürmer, Claudia

Adaptive Plasticity of Xenopus Glial Cells In Vitro and After CNS Fiber Tract Lesions In Vivo

Dateien

Adaptive_plasticity_of_Xenopus.pdfGröße: 5.17 MBDownloads: 452

Datum

1996

Autor:innen

Lang, Dirk M.

Stürmer, Claudia

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

GLIA. 1996, 18(2), pp. 92-106. ISSN 0894-1491. eISSN 1098-1136. Available under: doi: 10.1002/(SICI)1098-1136(199610)18:2<92::AID-GLIA2>3.0.CO;2-E

Zusammenfassung

Xenopus oligodendrocytes and aspects of their differentiation were analyzed in vitro and in vivo using cell- and stage-specific antibodies. Undifferentiated oligodendrocytes were derived from optic nerves or spinal cords. They divided in vitro, were of elongated shape, were glial fibrillary acidic protein and 04 positive, transiently exhibited several antigens including HNK-1 and L1, and promoted axon growth as do Schwann cells. With forskolin they differentiated and, much like myelin-forming oligodendrocytes in the intact optic nerve and spinal cord, they expressed sets of advanced myelin markers. These advanced myelin markers disappeared from the regenerating optic nerve 4 weeks after lesion. The optic nerve instead was populated by cells with radial processes and somata in the center of the nerve; among them were cells and processes that were 04 positive and that are suspected to represent undifferentiated oligodendrocytes. Where processes of these cells reached to the retinal axons in the nerve s periphery, advanced myelin markers typical of differentiated oligodendrocytes reappeared 8 weeks after lesion. These glial changes did not occur in the absence of retinal axons. Thus, the apparent capability of Xenopus oligodendrocytes to adapt to the transient absence, reappearance, and regenerative state of the axons enables them to contribute to central nervous system fiber tract repair. This occurs in the lesioned optic nerve but not in the spinal cord, where no such glial changes were observed and where axons fail to regenerate.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

Oligodendrocytes, differentiation, optic nerve, spinal cord

Zitieren

ISO 690

LANG, Dirk M., Claudia STÜRMER, 1996. Adaptive Plasticity of Xenopus Glial Cells In Vitro and After CNS Fiber Tract Lesions In Vivo. In: GLIA. 1996, 18(2), pp. 92-106. ISSN 0894-1491. eISSN 1098-1136. Available under: doi: 10.1002/(SICI)1098-1136(199610)18:2<92::AID-GLIA2>3.0.CO;2-E

BibTex

@article{Lang1996Adapt-6593,
  year={1996},
  doi={10.1002/(SICI)1098-1136(199610)18:2<92::AID-GLIA2>3.0.CO;2-E},
  title={Adaptive Plasticity of Xenopus Glial Cells In Vitro and After CNS Fiber Tract Lesions In Vivo},
  number={2},
  volume={18},
  issn={0894-1491},
  journal={GLIA},
  pages={92--106},
  author={Lang, Dirk M. and Stürmer, Claudia}
}

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Universitätsbibliographie

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