Topographic Restriction of TAG-1 Expression in the Developing Retinotectal Pathway and Target Dependent Reexpression during Axon Regeneration

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2001
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Lang, Dirk M.
Warren, James T.
Klisa, Christiane
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Molecular and Cellular Neuroscience. 2001, 17(2), pp. 398-414. ISSN 1044-7431. Available under: doi: 10.1006/mcne.2000.0936
Zusammenfassung

TAG-1, a glycosylphosphatidyl inositol (GPI)-anchored protein of the immunoglobulin (Ig) superfamily, exhibits an unusual spatiotemporal expression pattern in the fish visual pathway. Using in situ hybridization and new antibodies (Abs) against fish TAG-1 we show that TAG-1 mRNA and anti-TAG-1 staining is restricted to nasal retinal ganglion cells (RGCs) in 24- to 72-h-old zebrafish embryos and in the adult, continuously growing goldfish retina. Anti-TAG-1 Abs selectively label nasal RGC axons in the nerve, optic tract, and tectum. Axotomized RGCs reexpress TAG-1, which occurs as late as 12 days after optic nerve lesion, when regenerating RGC axons arrive in the tectum, suggesting TAG-1 reexpression is target contactdependent. Accordingly, TAG-1 reexpression ceases upon interruption of the regenerating projection by a second lesion. The topographic restriction of TAG-1 expression and its target dependency during regeneration suggests that TAG-1 might play a role in the retinotopic organization and restoration of the retinotectal pathway.

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570 Biowissenschaften, Biologie
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ISO 690LANG, Dirk M., James T. WARREN, Christiane KLISA, Claudia STÃœRMER, 2001. Topographic Restriction of TAG-1 Expression in the Developing Retinotectal Pathway and Target Dependent Reexpression during Axon Regeneration. In: Molecular and Cellular Neuroscience. 2001, 17(2), pp. 398-414. ISSN 1044-7431. Available under: doi: 10.1006/mcne.2000.0936
BibTex
@article{Lang2001Topog-8760,
  year={2001},
  doi={10.1006/mcne.2000.0936},
  title={Topographic Restriction of TAG-1 Expression in the Developing Retinotectal Pathway and Target Dependent Reexpression during Axon Regeneration},
  number={2},
  volume={17},
  issn={1044-7431},
  journal={Molecular and Cellular Neuroscience},
  pages={398--414},
  author={Lang, Dirk M. and Warren, James T. and Klisa, Christiane and Stürmer, Claudia}
}
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