Identification of Nogo-66 Receptor (NgR) and Homologous Genes in Fish

Klinger, Michael; Taylor, John S.; Oertle, Thomas; Schwab, Martin E.; Stürmer, Claudia; Diekmann, Heike

Identification of Nogo-66 Receptor (NgR) and Homologous Genes in Fish

Dateien

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Datum

2004

Autor:innen

Klinger, Michael

Taylor, John S.

Oertle, Thomas

Schwab, Martin E.

Stürmer, Claudia

Diekmann, Heike

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Molecular Biology and Evolution. 2004, 21(1), pp. 76-85. ISSN 0737-4038. eISSN 1537-1719. Available under: doi: 10.1093/molbev/msg241

Zusammenfassung

The Nogo-66 receptor NgR has been implicated in the mediation of inhibitory effects of central nervous system (CNS) myelin on axon growth in the adult mammalian CNS. NgR binds to several myelin-associated ligands (Nogo-66, myelin associated glycoprotein, and oligodendrocyte-myelin glycoprotein), which, among other inhibitory proteins, impair axonal regeneration in the CNS of adult mammals. In contrast to mammals, severed axons readily regenerate in the fish CNS. Nevertheless, fish axons are repelled by mammalian oligodendrocytes in vitro. Therefore, the identification of fish NgR homologs is a crucial step towards understanding NgR functions in vertebrate systems competent of CNS regeneration. Here, we report the discovery of four zebrafish (Danio rerio) and five fugu (Takifugu rubripes) NgR homologs. Synteny between fish and human, comparable intron-exon structures, and phylogenetic analyses provide convincing evidence that the true fish orthologs were identified. The topology of the phylogenetic trees shows that the extra fish genes were produced by duplication events that occurred in ray-finned fishes before the divergence of the zebrafish and pufferfish lineages. Expression of zebrafish NgR homologs was detected relatively early in development and prominently in the adult brain, suggesting functions in axon growth, guidance, or plasticity.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

NgR, Danio rerio, Fugu rubripes, Reticulon, gene duplication, conserved synteny

Zitieren

ISO 690

KLINGER, Michael, John S. TAYLOR, Thomas OERTLE, Martin E. SCHWAB, Claudia STÜRMER, Heike DIEKMANN, 2004. Identification of Nogo-66 Receptor (NgR) and Homologous Genes in Fish. In: Molecular Biology and Evolution. 2004, 21(1), pp. 76-85. ISSN 0737-4038. eISSN 1537-1719. Available under: doi: 10.1093/molbev/msg241

BibTex

@article{Klinger2004Ident-7896,
  year={2004},
  doi={10.1093/molbev/msg241},
  title={Identification of Nogo-66 Receptor (NgR) and Homologous Genes in Fish},
  number={1},
  volume={21},
  issn={0737-4038},
  journal={Molecular Biology and Evolution},
  pages={76--85},
  author={Klinger, Michael and Taylor, John S. and Oertle, Thomas and Schwab, Martin E. and Stürmer, Claudia and Diekmann, Heike}
}

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Universitätsbibliographie

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