Integrin-mediated invasion of Staphylococcus aureus into human cells requires Src family protein-tyrosine kinases

Agerer, Franziska; Michel, Antje; Ohlsen, Knut; Hauck, Christof R.

Integrin-mediated invasion of Staphylococcus aureus into human cells requires Src family protein-tyrosine kinases

Dateien

Integrin_mediated_invasion_of_Staphylococcus_aureus.pdfGröße: 463.84 KBDownloads: 708

Datum

2003

Autor:innen

Agerer, Franziska

Michel, Antje

Ohlsen, Knut

Hauck, Christof R.

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Journal of Biological Chemistry. 2003, 278(43), pp. 42524-42531. ISSN 0021-9258. eISSN 1083-351X. Available under: doi: 10.1074/jbc.M302096200

Zusammenfassung

Staphylococcus aureus, a common cause of nosocomial infections, is able to invade eukaryotic cells by indirectly engaging 1 integrin-containing host receptors, whereas non-pathogenic Staphylococcus carnosus is not invasive. Here, we identify intracellular signals involved in integrin-initiated internalization of S. aureus. In particular, the host cell actin cytoskeleton and Src family protein-tyrosine kinases (PTKs) are essential to mediate S. aureus invasion. Src PTKs are activated in response to pathogenic S. aureus, but not S. carnosus. In addition, pharmacological and genetic interference with Src PTK function reduces bacterial internalization. Importantly, Src PTK-deficient cells are resistant to S. aureus invasion, demonstrating the essentiality of host Src PTKs in integrin-mediated uptake of this pathogen.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

AGERER, Franziska, Antje MICHEL, Knut OHLSEN, Christof R. HAUCK, 2003. Integrin-mediated invasion of Staphylococcus aureus into human cells requires Src family protein-tyrosine kinases. In: Journal of Biological Chemistry. 2003, 278(43), pp. 42524-42531. ISSN 0021-9258. eISSN 1083-351X. Available under: doi: 10.1074/jbc.M302096200

BibTex

@article{Agerer2003Integ-7617,
  year={2003},
  doi={10.1074/jbc.M302096200},
  title={Integrin-mediated invasion of Staphylococcus aureus into human cells requires Src family protein-tyrosine kinases},
  number={43},
  volume={278},
  issn={0021-9258},
  journal={Journal of Biological Chemistry},
  pages={42524--42531},
  author={Agerer, Franziska and Michel, Antje and Ohlsen, Knut and Hauck, Christof R.}
}

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