Reorganization of auditory cortex in tinnitus

Mühlnickel, Werner; Elbert, Thomas; Taub, Edward; Flor, Herta

Reorganization of auditory cortex in tinnitus

Dateien

Reorganization_of_auditory_cortex_in_tinnitus.pdfGröße: 216.94 KBDownloads: 397

Datum

1998

Autor:innen

Mühlnickel, Werner

Elbert, Thomas

Taub, Edward

Flor, Herta

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Psychologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Proceedings of the National Academy of Sciences. 1998, 95(17), pp. 10340-10343. ISSN 0027-8424. eISSN 1091-6490. Available under: doi: 10.1073/pnas.95.17.10340

Zusammenfassung

Magnetic source imaging was used to determine whether tonotopy in auditory cortex of individuals with tinnitus diverges from normative functional organization. Ten tinnitus subjects and 15 healthy controls were exposed to four sets of tones while magnetoencephalographic recordings were obtained from the two cortical hemispheres in sequence. A marked shift of the cortical representation of the tinnitus frequency into an area adjacent to the expected tonotopic location was observed. The Euclidean distance of the tinnitus frequency from the trajectory of the tonotopic map was 5.3 mm(SD=3.1) compared with a distance of 2.5mm(SD=1.3) of a corresponding frequency in the healthy controls (t=3.13, P < 0.01). In addition, a strong positive correlation was found between the subjective strength of the tinnitus and the amount of cortical reorganization (r=0.82, P < 0.01). These results demonstrate that tinnitus is related to plastic alterations in auditory cortex. Similarities between these data and the previous demonstrations that phantom limb pain is highly correlated with cortical reorganization suggest that tinnitus may be an auditory phantom phenomenon.

Fachgebiet (DDC)

150 Psychologie

Schlagwörter

plasticity, magnetic source imaging

Zitieren

ISO 690

MÜHLNICKEL, Werner, Thomas ELBERT, Edward TAUB, Herta FLOR, 1998. Reorganization of auditory cortex in tinnitus. In: Proceedings of the National Academy of Sciences. 1998, 95(17), pp. 10340-10343. ISSN 0027-8424. eISSN 1091-6490. Available under: doi: 10.1073/pnas.95.17.10340

BibTex

@article{Muhlnickel1998Reorg-10790,
  year={1998},
  doi={10.1073/pnas.95.17.10340},
  title={Reorganization of auditory cortex in tinnitus},
  number={17},
  volume={95},
  issn={0027-8424},
  journal={Proceedings of the National Academy of Sciences},
  pages={10340--10343},
  author={Mühlnickel, Werner and Elbert, Thomas and Taub, Edward and Flor, Herta}
}

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