One-Pot Procedure for Diazo Transfer and Azide-Alkyne Cycloaddition : Triazole Linkages from Amines

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2007
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Beckmann, Henning S. G.
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Organic Letters. 2007, 9(1), pp. 1-4. ISSN 1523-7060. eISSN 1523-7052. Available under: doi: 10.1021/ol0621506
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A one-pot reaction for Cu(II)-catalyzed diazo transfer and Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (sometimes called click reaction) is reported. 1,4-Disubstituted 1,2,3-triazoles are obtained in excellent yields from a variety of readily available amines without the need for isolation of the azide intermediates. The reaction has a broad scope and is especially practical for the synthesis of multivalent structures because compounds substituted with multiple azides are potentially unstable.

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ISO 690BECKMANN, Henning S. G., Valentin WITTMANN, 2007. One-Pot Procedure for Diazo Transfer and Azide-Alkyne Cycloaddition : Triazole Linkages from Amines. In: Organic Letters. 2007, 9(1), pp. 1-4. ISSN 1523-7060. eISSN 1523-7052. Available under: doi: 10.1021/ol0621506
BibTex
@article{Beckmann2007OnePo-9883,
  year={2007},
  doi={10.1021/ol0621506},
  title={One-Pot Procedure for Diazo Transfer and Azide-Alkyne Cycloaddition : Triazole Linkages from Amines},
  number={1},
  volume={9},
  issn={1523-7060},
  journal={Organic Letters},
  pages={1--4},
  author={Beckmann, Henning S. G. and Wittmann, Valentin}
}
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