@article{Perlstein2002Disso-11067,
  year={2002},
  title={Dissociation in human prefrontal cortex of affective influences on working memory-related activity},
  number={3},
  volume={99},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  pages={1736--1741},
  author={Perlstein, William M. and Elbert, Thomas and Stenger, V. Andrew}
}

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    <dc:creator>Stenger, V. Andrew</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-25T09:25:16Z</dc:date>
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    <dc:contributor>Perlstein, William M.</dc:contributor>
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    <dc:contributor>Stenger, V. Andrew</dc:contributor>
    <dcterms:abstract xml:lang="eng">Although neural activity associated with emotion is becoming better understood, the influence of affective parameters on brain activity reflecting cognitive functioning in humans remains poorly characterized. We examined affective influences on working memory (WM) and tested the hypotheses that (i) dorsolateral prefrontal cortex (DLPFC) activity reflecting WM is influenced by the emotion-evoking qualities of task-relevant stimuli, but only when brought "on-line" by task demands, and (ii) DLPFC and orbitofrontal cortex (OFC) activities are inversely related as a function of emotional valence. Participants performed two tasks while event-related functional MRI measured brain activity; one task required active maintenance of stimulus representations in WM, and the other task required target detection responses with no demand for WM. Stimuli were standardized emotional (pleasant and unpleasant) and neutral pictures. Emotional stimuli differentially influenced DPFC and OFC activity during WM; DLPFC was influenced by emotional valence, enhanced by pleasant and reduced by unpleasant, compared to neutral stimuli, only when task conditions required WM. OFC was valence-sensitive during both tasks, greater to arousing than neutral stimuli when WM demand was low and in inverse relationship to DLPFC with high WM demand. Further, DLPFC and OFC activities are inversely related with respect to emotional valence during the WM task. The results are consistent with the hypothesis that the intrinsic valence of task-relevant stimuli maintained in WM modulates DLPFC activity but only when the DLPFC is required for task demands. Findings suggest a conceptualization of DLPFC and its involvement in WM that takes into account a role for affective parameters.</dcterms:abstract>
    <dcterms:issued>2002</dcterms:issued>
    <dcterms:title>Dissociation in human prefrontal cortex of affective influences on working memory-related activity</dcterms:title>
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    <dc:creator>Elbert, Thomas</dc:creator>
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    <dc:creator>Perlstein, William M.</dc:creator>
    <dcterms:bibliographicCitation>First publ. in: Proceedings of the National Academy of Sciences of the United States of America 99 (2002), 3, pp. 1736-1741</dcterms:bibliographicCitation>
    <dc:contributor>Elbert, Thomas</dc:contributor>
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