The re-establishment of synaptic transmission by regenerating optic axons in goldfish : time course and effects of blocking activity by intraocular injection of tetrodotoxin

Schmidt, John T.; Edwards, D. L.; Stürmer, Claudia

The re-establishment of synaptic transmission by regenerating optic axons in goldfish : time course and effects of blocking activity by intraocular injection of tetrodotoxin

Dateien

The_re_establishment_of_synaptic_transmission_by_regenerating_optic_axons_in_goldfish.pdfGröße: 2 MBDownloads: 316

Datum

1983

Autor:innen

Schmidt, John T.

Edwards, D. L.

Stürmer, Claudia

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Brain Research. 1983, 269(1), pp. 15-27. ISSN 0006-8993. Available under: doi: 10.1016/0006-8993(83)90958-7

Zusammenfassung

Intraocular injections of tetrodotoxin were used to block activity for 27 days in normal fish and for the first 27 or 31 days of regeneration in fish with one optic nerve crushed. Synaptic activity was then assessed by a current source-density analysis of field potentials evoked by optic nerve shock at different times following the TTX treatment. In normal fish, the lack of activity for 4 weeks had no significant effect on the maintenance of synaptic strength. Likewise, in fish with nerve crush, lack of activity did not prevent the regenerating optic fibers from forming synapses that were nearly as effective as those formed in controls injected with the citrate buffer vehicle. The earliest synapses were formed at the rostromedial corner of the tectum (where the tract enters) at 20 days after nerve crush, when fibers had not yet reached the caudal areas. By 28 days synaptic potentials could be recorded everywhere on the surface of the tectum in both controls and TTX injected fish. However, the latency of the responseswith TTX were longer, suggesting a smaller caliber of fiber, which is consistent with an earlier finding of decreased axonal transport in TTX fish6. Maturation of the regenerating fibers proceeded slowly in both TTX and control fish. After more than 5 months, the projections were nearly normal but still not completely normal.

Fachgebiet (DDC)

380 Handel, Kommunikation, Verkehr

Schlagwörter

synaptic transmission, nerve regeneration, axonal transport, goldfish optic nerve, tetrodotoxin

Zitieren

ISO 690

SCHMIDT, John T., D. L. EDWARDS, Claudia STÜRMER, 1983. The re-establishment of synaptic transmission by regenerating optic axons in goldfish : time course and effects of blocking activity by intraocular injection of tetrodotoxin. In: Brain Research. 1983, 269(1), pp. 15-27. ISSN 0006-8993. Available under: doi: 10.1016/0006-8993(83)90958-7

BibTex

@article{Schmidt1983reest-8584,
  year={1983},
  doi={10.1016/0006-8993(83)90958-7},
  title={The re-establishment of synaptic transmission by regenerating optic axons in goldfish : time course and effects of blocking activity by intraocular injection of tetrodotoxin},
  number={1},
  volume={269},
  issn={0006-8993},
  journal={Brain Research},
  pages={15--27},
  author={Schmidt, John T. and Edwards, D. L. and Stürmer, Claudia}
}

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