@article{Kathner1992Dynam-7215,
  year={1992},
  title={Dynamics of terminal arbor formation and target approach of retinotectal axons in living zebrafish embryos : a time-lapse study of single axons},
  number={8},
  volume={12},
  journal={Journal of Neuroscience},
  pages={3257--3271},
  author={Käthner, Rolf J. and Stürmer, Claudia}
}

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    <dc:contributor>Stürmer, Claudia</dc:contributor>
    <dcterms:abstract xml:lang="deu">In a variety of species, developing retinal axons branch initially more widely in their visual target centers and only gradually restrict their terminal arbors to smaller and defined territories. Retinotectal axons in fish, however, appeared to grow in a directed manner and to arborize only at their retinotopic target sites. To visualize the dynamics of retinal axon growth and arbor formation in fish, time-lapse recordings were made of individual retinal ganglion cell axons in the tectum in live zebrafish embryos. Axons were labeled with the fluorescent carbocyanine dyes Dil or DiO inserted as crystals into defined regions of the retina, viewed with 40x and 100x objectives with an SIT camera, and recorded, with exposure times of 200 msec at 30 or 60 sec intervals, over time periods of up to 13 hr. (1) Growth cones advanced rapidly, but the advance was punctuated by periods of rest. During the rest periods, the growth cones broadened and developed filopodia, but during extension they were more streamlined. (2) Growth cones traveled unerringly into the direction of their retinotopic targets without branching en route. At their target and only there, the axons began to form terminal arborizations, a process that involved the emission and retraction of numerous short side branches. The area that was permanently occupied or touched by transient branches of the terminal arbor - "the exploration field" - was small and almost circular and covered not more than 5.3% of the entire tectal surface area, but represented up to six times the size of the arbor at any one time. These findings are consistent with the idea that retinal axons are guided to their retinotopic target sites by sets of positional markers, with a graded distribution over the axes of the tectum.</dcterms:abstract>
    <dcterms:title>Dynamics of terminal arbor formation and target approach of retinotectal axons in living zebrafish embryos : a time-lapse study of single axons</dcterms:title>
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    <dcterms:issued>1992</dcterms:issued>
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    <dc:language>eng</dc:language>
    <dc:contributor>Käthner, Rolf J.</dc:contributor>
    <dc:creator>Stürmer, Claudia</dc:creator>
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    <dc:creator>Käthner, Rolf J.</dc:creator>
    <dcterms:bibliographicCitation>First publ. in: Journal of Neuroscience 12 (1992), 8, pp. 3257-3271</dcterms:bibliographicCitation>
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