@article{StuderRohr2000Kinet-6966,
  year={2000},
  title={Kinetic parameters and intraindividual fluctuations of ochratoxin A plasma levels in humans},
  number={9},
  volume={74},
  issn={0340-5761},
  journal={Archives of Toxicology},
  pages={499--510},
  author={Studer-Rohr, Irène and Schlatter, Josef and Dietrich, Daniel R.}
}

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    <dc:creator>Schlatter, Josef</dc:creator>
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    <dc:contributor>Dietrich, Daniel R.</dc:contributor>
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    <dcterms:bibliographicCitation>First publ. in: Archives of Toxicology 74 (2000), 9, pp. 499-510</dcterms:bibliographicCitation>
    <dc:contributor>Schlatter, Josef</dc:contributor>
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    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:30:29Z</dc:date>
    <dcterms:title>Kinetic parameters and intraindividual fluctuations of ochratoxin A plasma levels in humans</dcterms:title>
    <dc:creator>Studer-Rohr, Irène</dc:creator>
    <dcterms:abstract xml:lang="eng">The mycotoxin ochratoxin A (OTA) is a rodent carcinogen produced by species of the ubiquitous fungal genera Aspergillus and Penicillium. OTA is found in a variety of food items and as a consequence is also found in human plasma (average concentrations found in this study: 0.1-1 ng OTA/ml plasma). To improve the scientific basis for cancer risk assessment the toxicokinetic profile of OTA was studied in one human volunteer following ingestion of 395 ng [3]H-labeled OTA (3.8 μCi). A two-compartment open model consisting of a central compartment was found to best describe the in vivo data. This two-compartment model consisted of a fast elimination and distribution phase (T[1/2] about 20 h) followed by a slow elimination phase (renal clearance about 0.11 ml/min.) and a calculated plasma half-life of 35.55 days. This half-life was approximately eight times longer than that determined previously in rats. In addition, the intraindividual fluctuation of OTA plasma levels was investigated in eight individuals over a period of 2 months. The concentrations determined ranged between 0.2 and 0.9 ng OTA/ml plasma. The plasma levels in some individuals remained nearly constant over time, while others varied considerably (e.g. increase of 0.4 ng/ml within 3 days, decrease of 0.3 ng/ml within 5 days) during the observation period. This intraindividual fluctuation in OTA plasma levels, which may represent differences in OTA exposure and/or metabolism, as well as the large difference in plasma half-life in humans compared to rats must be taken into consideration when the results of rat cancer study data are extrapolated to humans for risk assessment purposes.</dcterms:abstract>
    <dc:creator>Dietrich, Daniel R.</dc:creator>
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