@article{Pils2008CEACA-8322,
  year={2008},
  doi={10.1016/j.ijmm.2008.04.005},
  title={CEACAM3: An innate immune receptor directed against human-restricted bacterial pathogens},
  number={7-8},
  volume={298},
  issn={1438-4221},
  journal={International Journal of Medical Microbiology},
  pages={553--560},
  author={Pils, Stefan and Gerrard, Dave T. and Meyer, Axel and Hauck, Christof R.}
}

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    <dc:contributor>Hauck, Christof R.</dc:contributor>
    <dc:contributor>Pils, Stefan</dc:contributor>
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    <dc:creator>Hauck, Christof R.</dc:creator>
    <dcterms:title>CEACAM3: An innate immune receptor directed against human-restricted bacterial pathogens</dcterms:title>
    <dc:creator>Meyer, Axel</dc:creator>
    <dc:contributor>Meyer, Axel</dc:contributor>
    <dc:creator>Pils, Stefan</dc:creator>
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    <dcterms:bibliographicCitation>First publ. in: International Journal of Medical Microbiology 298 (2008), 7-8, pp. 553-560</dcterms:bibliographicCitation>
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    <dc:contributor>Gerrard, Dave T.</dc:contributor>
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    <dcterms:abstract xml:lang="eng">Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) is an immunoglobulin-related glycoprotein exclusively expressed on granulocytes. In contrast to other members of the CEACAM family, CEACAM3 does not support cell cell adhesion, but rather mediates the opsonin-independent recognition and elimination of a restricted set of human-specific Gram-negative bacterial pathogens including Neisseria gonorrhoeae, Haemophilus influenzae, and Moraxella catarrhalis. Within the last 4 years, molecular determinants of CEACAM3 function and CEACAM3-initiated signaling pathways have been elucidated. Sequence comparison between CEACAM3 and other CEACAM family members points to a chimeric origin of this receptor with the bacteriabinding extracellular domain and the function-promoting intracellular domain derived from different genes. This review summarizes the current knowledge about the structure function relationship of CEACAM3 and tries to combine these molecular aspects with a plausible scenario concerning the evolutionary origin of this phagocyte receptor in the light of host pathogen adaptation.</dcterms:abstract>
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    <dc:creator>Gerrard, Dave T.</dc:creator>
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