Evolution of Receptors for Growth Hormone and Somatolactin in Fish and Land Vertebrates : Lessons from the Lungfish and Sturgeon Orthologues

Fukamachi, Shoji; Meyer, Axel

Evolution of Receptors for Growth Hormone and Somatolactin in Fish and Land Vertebrates : Lessons from the Lungfish and Sturgeon Orthologues

Dateien

Evolution_of_Receptors_for_Growth_Hormone_and_Somatolactin_in_Fish_and_Land_Vertebrates.pdfGröße: 712.75 KBDownloads: 764

Datum

2007

Autor:innen

Fukamachi, Shoji

Meyer, Axel

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Journal of Molecular Evolution. 2007, 65(4), pp. 359-372. ISSN 0022-2844. eISSN 1432-1432. Available under: doi: 10.1007/s00239-007-9035-7

Zusammenfassung

Two cognate hormones, growth hormone (GH) and somatolactin (SL), control several important physiological processes in vertebrates. Knowledge about GH and its receptor (GHR) has accumulated over the last decades. However, much less is known about SL and its receptor (SLR). SL is found only in fish (including lungfish), suggesting that it was present in the common ancestor of vertebrates, but was lost secondarily in the lineage leading to land vertebrates after the lungfish branched off. SLR was suggested to be a duplicated copy of GHR acquired only in teleosts via the fish-specific genome duplication (FSGD). This scenario (i.e., the existence of SL but not SLR in the vertebrate ancestors) is intriguing but contested. In this study, we first evaluated the plausibility of this scenario through synteny analyses and found that the loci for GHR and SLR are located in syntenic genomic positions, whereas the loci for GH and SL are not. Next, we cloned GHRs of lungfish and sturgeon, which possess SL but did not undergo the FSGD (i.e., they should not possess SLR). Their phylogenetic positions in the GHR/SLR gene tree further support the fish-specific scenario for the GHR SLR duplication. Interestingly, their sequences share greater similarity with teleost SLRs and reptilian/amphibian GHRs than with the GHRs of mammals, birds, and teleosts. On the basis of these results, we discuss the validity of the nomenclature of the teleost-specific copy of GHR as SLR and an ancestral receptor(s) for SL before the evolution of SLR during the FSGD.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

Somatolactin receptor (SLR), Growth hormone receptor (GHR), Lungfish, Sturgeon, Fish-specific genome duplication (FSGD)

Zitieren

ISO 690

FUKAMACHI, Shoji, Axel MEYER, 2007. Evolution of Receptors for Growth Hormone and Somatolactin in Fish and Land Vertebrates : Lessons from the Lungfish and Sturgeon Orthologues. In: Journal of Molecular Evolution. 2007, 65(4), pp. 359-372. ISSN 0022-2844. eISSN 1432-1432. Available under: doi: 10.1007/s00239-007-9035-7

BibTex

@article{Fukamachi2007Evolu-7677,
  year={2007},
  doi={10.1007/s00239-007-9035-7},
  title={Evolution of Receptors for Growth Hormone and Somatolactin in Fish and Land Vertebrates : Lessons from the Lungfish and Sturgeon Orthologues},
  number={4},
  volume={65},
  issn={0022-2844},
  journal={Journal of Molecular Evolution},
  pages={359--372},
  author={Fukamachi, Shoji and Meyer, Axel}
}

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Universitätsbibliographie

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