Cytokine induction by Gram-positive bacteria

Draing, Christian; Sigel, Stefanie; Deininger, Susanne; Traub, Stephanie; Munke, Rebekka; Mayer, Christoph; Hareng, Lars; Hartung, Thomas; Aulock, Sonja von; Hermann, Corinna

Cytokine induction by Gram-positive bacteria

Dateien

Draing_Immunobiol_2008.pdfGröße: 7.78 MBDownloads: 971

Datum

2008

Autor:innen

Draing, Christian

Sigel, Stefanie

Deininger, Susanne

Traub, Stephanie

Munke, Rebekka

Mayer, Christoph

Hareng, Lars

Hartung, Thomas

Aulock, Sonja von

Hermann, Corinna

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie
Zukunftskolleg

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Immunobiology. 2008, 213(3-4), pp. 285-296. ISSN 0171-2985. eISSN 1878-3279. Available under: doi: 10.1016/j.imbio.2007.12.001

Zusammenfassung

Despite similar clinical relevance of Gram-positive and Gram-negative infections, immune activation by Grampositive bacteria is by far less well understood than immune activation by Gram-negative bacteria. Our group has made available highly purified lipoteichoic acids (LTA) as a key Gram-positive immunostimulatory component. We have characterized the reasons for lower potency of LTA compared to Gram-negative lipopolysaccharide (LPS), identifying lack of IL-12/IFNgamma induction as a general characteristic of TLR2 agonists, and need for presentation of LTA on surfaces for enhanced immunostimulatory potency, as major aspects. Aspects of chemokine induction, where LTA is more potent than LPS, have been addressed. Furthermore, novel complement and plant defence activation, as well as CD36 as a new LTA receptor, were identified. The bacterial costimuli and modulators of LTA inducible responses are being investigated: LTA isolated from so far 16 bacterial species, although different in structure, behave remarkably similar while whole live and killed bacteria differ with regard to the pattern of induced responses. The purification and characterization of the respective components of the bacterial cell wall has begun.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

Inate immunity, Gram-positive bacteria, Lipoteichoic acid, Cytokines, Monocytes

Zitieren

ISO 690

DRAING, Christian, Stefanie SIGEL, Susanne DEININGER, Stephanie TRAUB, Rebekka MUNKE, Christoph MAYER, Lars HARENG, Thomas HARTUNG, Sonja von AULOCK, Corinna HERMANN, 2008. Cytokine induction by Gram-positive bacteria. In: Immunobiology. 2008, 213(3-4), pp. 285-296. ISSN 0171-2985. eISSN 1878-3279. Available under: doi: 10.1016/j.imbio.2007.12.001

BibTex

@article{Draing2008Cytok-8653,
  year={2008},
  doi={10.1016/j.imbio.2007.12.001},
  title={Cytokine induction by Gram-positive bacteria},
  number={3-4},
  volume={213},
  issn={0171-2985},
  journal={Immunobiology},
  pages={285--296},
  author={Draing, Christian and Sigel, Stefanie and Deininger, Susanne and Traub, Stephanie and Munke, Rebekka and Mayer, Christoph and Hareng, Lars and Hartung, Thomas and Aulock, Sonja von and Hermann, Corinna}
}

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Universitätsbibliographie

Ja