@article{Fittipaldi2008DAlan-6568,
  year={2008},
  doi={10.1128/IAI.01568-07},
  title={D-Alanylation of Lipoteichoic Acid Contributes to the Virulence of Streptococcus suis},
  number={8},
  volume={76},
  issn={0019-9567},
  journal={Infection and immunity},
  pages={3587--3594},
  author={Fittipaldi, Nahuel and Sekizaki, Tsutomu and Takamatsu, Daisuke and Harel, Josée and Cruz Domínguez-Punaro, María de la and Aulock, Sonja von and Draing, Christian and Marois, Corinne and Kobisch, Marylène and Gottschalk, Marcelo}
}

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    <dc:creator>Fittipaldi, Nahuel</dc:creator>
    <dcterms:bibliographicCitation>First publ. in: Infection and immunity 76 (2008), 8, pp. 3587 3594</dcterms:bibliographicCitation>
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    <dc:contributor>Fittipaldi, Nahuel</dc:contributor>
    <dc:creator>Takamatsu, Daisuke</dc:creator>
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    <dcterms:title>D-Alanylation of Lipoteichoic Acid Contributes to the Virulence of Streptococcus suis</dcterms:title>
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    <dcterms:abstract xml:lang="eng">We generated by allelic replacement a Delta dlt A mutant of a virulent Streptococcus suis serotype 2 field strain and evaluated the contribution of lipoteichoic acid (LTA) D-alanylation to the virulence traits of this swine pathogen and zoonotic agent. The absence of LTA D-alanylation resulted in increased susceptibility to the action of cationic antimicrobial peptides. In addition, and in contrast to the wild-type strain, the Delta dltA mutant was efficiently killed by porcine neutrophils and showed diminished adherence to and invasion of porcine brain microvascular endothelial cells. Finally, the Delta dltA mutant was attenuated in both the CD1 mouse and porcine models of infection, probably reflecting a decreased ability to escape immune clearance mechanisms and an impaired capacity to move across host barriers. The results of this study suggest that LTA D-alanylation is an important factor in S. suis virulence.</dcterms:abstract>
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    <dc:contributor>Harel, Josée</dc:contributor>
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    <dc:creator>Harel, Josée</dc:creator>
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    <dc:contributor>Sekizaki, Tsutomu</dc:contributor>
    <dc:contributor>Draing, Christian</dc:contributor>
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